Phytochemical Profiling and Biological Testing of the Constituents of the Australian Plant .

J Nat Prod

School of Science (Applied Chemistry and Environmental Science), RMIT University, GPO Box 2476, Melbourne, Victoria 3001, Australia.

Published: November 2021

Phytochemical profiling was undertaken on the crude extracts of the bulbs, stems, and the fruits of , to determine the nature of the chemical constituents present. This represents the first study to investigate the fruits of a species of . In total, 13 new and 17 previously reported compounds were isolated and identified. The new compounds were of the phenylphenalenone-type class, with a representative of a novel structural form, named tentatively "oxabenzochromenone" (), a compound akin to an intermediate in a recently proposed phenylphenalenone metabolic network (), seven new phenylphenalenones (-), four new phenylbenzoisochromenones (-), and a new phenylbenzoisochromenone derivative (). The previously reported compounds identified were of the following structure classes: oxabenzochrysenone (, -), flavonol (, ), phenylbenzoisochromenone (, , , -), and phenylphenalenone (, ). Compounds -, -, -, , , and were subjected to antimicrobial evaluation with moderate activity observed against MRSA and slight activity against and . Compounds , -, , and were also evaluated for anthelminthic activity against larvae of the blood-feeding parasitic nematode .

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http://dx.doi.org/10.1021/acs.jnatprod.1c00509DOI Listing

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