Visible light-activatable Q-dye molecular beacons for long-term mRNA monitoring in neurons.

Chem Commun (Camb)

Institute of Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Straße 9, Frankfurt am Main 60438, Germany.

Published: November 2021

Herein, we present a new class of Q-dye molecular beacons (MBs) that can be locally activated with visible light in hippocampal neurons. Our novel architecture increases the available monitoring time for neuronal mRNA from several minutes to 14 hours, since a lower light-sampling rate is required for tracking.

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Source
http://dx.doi.org/10.1039/d1cc05664fDOI Listing

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