AI Article Synopsis
- Iron-catalyzed method allows for efficient dehydroxyboration of allylic alcohols to create ()-stereoselective allylboronates.
- The process is effective for a variety of allylic alcohols, particularly those from natural products.
- A six-membered ring transition state involving allylic alcohols and an iron-boron intermediate plays a crucial role in transferring the boron group, activating the C-OH bond, and ensuring stereoselectivity.
Article Abstract
Iron-catalyzed direct S2' dehydroxyboration of allylic alcohols has been developed to access ()-stereoselective allylboronates. Allylic alcohols with diverse structures and functional groups, especially derived from natural products, underwent smooth transformation. The six-membered ring transition state formed by allylic alcohols and iron-boron intermediate was indicated to be the key component involved in transfer of the boron group, activation of the C-OH bond, and control of the stereoselectivity.
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| http://dx.doi.org/10.1021/acs.orglett.1c03359 | DOI Listing |
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