AI Article Synopsis
- Mechanical forces are used to analyze how macromolecules interact at the molecular level, particularly focusing on nonspecific interactions between cholesterol molecules.
- Using optical tweezers, researchers discovered that the intermolecular mechanical forces (IMMF) when cholesterols form pairs are influenced by their orientation and can reach values similar to the stability of DNA structures (around 30 pN).
- The study also revealed that the presence of β-cyclodextrin and methylated β-cyclodextrin significantly enhances the solubility of cholesterol, demonstrating that IMMF can be a valuable tool for understanding these types of interactions in detail.
Article Abstract
Mechanical force can evaluate intramolecular interactions in macromolecules. Because of the rapid motion of small molecules, it is extremely challenging to measure mechanical forces of nonspecific intermolecular interactions. Here, we used optical tweezers to directly examine the intermolecular mechanical force (IMMF) of nonspecific interactions between two cholesterols. We found that IMMFs of dimeric cholesterol complexes were dependent on the orientation of the interaction. The surprisingly high IMMF in cholesterol dimers (∼30 pN) is comparable to the mechanical stability of DNA secondary structures. Using Hess-like cycles, we quantified that changes in free energy of solubilizing cholesterol (Δ) by β-cyclodextrin (βCD) and methylated βCD (Me-βCD) were as low as -16 and -27 kcal/mol, respectively. Compared to the Δ of cholesterols in water (5.1 kcal/mol), these values indicated that cyclodextrins can easily solubilize cholesterols. Our results demonstrated that the IMMF can serve as a generic and multipurpose variable to dissect nonspecific intermolecular interactions among small molecules into orientational components.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778946 | PMC |
| http://dx.doi.org/10.1021/acs.jpclett.1c03142 | DOI Listing |
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