By means of the formation of SeN, the ABT-Se and NDI-Se were developed to detect and visualize endogenous hypobromous acid (HOBr) in live cells. Specifically, the upregulation of HOBr was monitored by NDI-Se during the administration of an immunotherapeutic agent.
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Rapid detection of hypobromous acid by a tetraphenylethylene-based turn-on fluorescent AIE probe and its applications.
Anal Chim Acta
June 2024
School of Chemistry, Key Laboratory of Advanced Technologies of Material, Minister of Education, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, China. Electronic address:
Background: Similar to hypochlorous acid (HClO), hypobromous acid (HBrO) is one of the most notable reactive oxygen species (ROS). Overexpression of HBrO is linked to various diseases causing organ and tissue loss. Due to HBrO's role in the oxidation of micropollutants, real-time monitoring of HBrO in water-based systems is essential.
View Article and Find Full Text PDFA novel benzothiazolin-based fluorescent probe for hypobromous acid and its application in environment and biosystems.
Talanta
January 2024
School of Water Conservancy and Environment, University of Jinan, Jinan, 250022, China.
Studies have shown that hypobromous acid (HOBr) produced during chlorination disinfection of tap water can react with some organic matter in water to form toxic brominated disinfection byproducts (Br-DBPs) and HOBr also plays an important role during the process of micro pollutants degradation. Hence, real-time monitoring of HOBr in water environment plays a significant role in controlling the generation of Br-DBPs and degradation of micro pollutants. Herein, a novel highly specific fluorescent probe (PBE-HOBr) for accurate detection of HOBr was constructed based on the HOBr-induced oxidation elimination of benzothiazoline moiety employing the photo-induced electron transfer (PET) mechanism.
View Article and Find Full Text PDFA novel mitochondria-targetable NIR fluorescent probe for monitoring intracellular hypobromous acid levels.
Anal Sci
September 2022
Center of Characterization and Analysis, Jilin Institute of Chemical Technology, Jilin, People's Republic of China.
The development of ultrasensitive in situ detection techniques for monitoring hypobromous acid (HBrO) levels in the biological systems is of great significance to reveal its complex pathological and physiological effects. A simple mitochondria-targetable hydrazine-based near-infrared (NIR) fluorescent probe (Mito-NIR) for detecting HBrO in the mitochondria of live cells is presented in this paper. Probe Mito-NIR displays the ultrafast (< 5 s) response for HBrO.
View Article and Find Full Text PDFHarnessing SeN to develop novel fluorescent probes for visualizing the variation of endogenous hypobromous acid (HOBr) during the administration of an immunotherapeutic agent.
Chem Commun (Camb)
November 2021
College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China.
By means of the formation of SeN, the ABT-Se and NDI-Se were developed to detect and visualize endogenous hypobromous acid (HOBr) in live cells. Specifically, the upregulation of HOBr was monitored by NDI-Se during the administration of an immunotherapeutic agent.
View Article and Find Full Text PDFUric Acid as a Photosensitizer in the Reaction of Deoxyribonucleosides with UV Light of Wavelength Longer than 300 nm: Identification of Products from 2'-Deoxycytidine.
Chem Pharm Bull (Tokyo)
December 2021
School of Pharmacy, Shujitsu University.
DNA reacts directly with UV light with a wavelength shorter than 300 nm. Although ground surface sunlight includes little of this short-wavelength UV light due to its almost complete absorption by the atmosphere, sunlight is the primary cause of skin cancer. Photosensitization by endogenous substances must therefore be involved in skin cancer development mechanisms.
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