Alkaloids from with inhibitory effect on nitric oxide production lipopolysaccharide-stimulated in RAW264.7 macrophages.

The chemical study of the acidic extract of leaves led to the isolation of one new alkaloid, vietnamine A () and eight known alkaloids (,)-2N-norberbamunine (), grisabine (), -dimethylgrisabine (), dauricine (), neothalibrine (), vietnamine (), xylopine (), and argentinine () by NMR and MS and comparing with the data reported in the literature. Compounds - were evaluated for inhibitory NO production in RAW 264.7 macrophages, LPS-stimulated. Compounds - significantly inhibited on NO production with the IC values of 6.8 ± 0.9, 9.8 ± 1.0, and 7.1 ± 0.4 µg/ml, respectively.