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Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes.
Proc Natl Acad Sci U S A
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Division of Basic Science, Fred Hutchinson Cancer Center, Seattle, WA 98109.
Mx proteins, first identified in mammals, encode potent antiviral activity against a wide range of viruses. Mx proteins arose within the Dynamin superfamily of proteins (DSP), which mediate critical cellular processes, such as endocytosis and mitochondrial, plastid, and peroxisomal dynamics. Despite their crucial role, the evolutionary origins of Mx proteins are poorly understood.
View Article and Find Full Text PDFEditorial: Fighting antimicrobial resistance in developing countries: innovative approaches and challenges.
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UK Centre for Ecology & Hydrology, Lancaster, United Kingdom.
Antibiotic-mediated dysbiosis leads to activation of inflammatory pathways.
Front Immunol
January 2025
Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.
Introduction: The gut microbiota plays a pivotal role in influencing host health, through the production of metabolites and other key signalling molecules. While the impact of specific metabolites or taxa on host cells is well-documented, the broader impact of a disrupted microbiota on immune homeostasis is less understood, which is particularly important in the context of the increasing overuse of antibiotics.
Methods: Female C57BL/6 mice were gavaged twice daily for four weeks with Vancomycin, Polymyxin B, or PBS (control).
ZBP1 senses DNA triggering type I interferon signaling pathway and unfolded protein response activation.
Front Immunol
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Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
The innate immune system promptly detects and responds to invading pathogens, with a key role played by the recognition of bacterial-derived DNA through pattern recognition receptors. The Z-DNA binding protein 1 (ZBP1) functions as a DNA sensor inducing type I interferon (IFN) production, innate immune responses and also inflammatory cell death. ZBP1 interacts with cytosolic DNA via its DNA-binding domains, crucial for its activation.
View Article and Find Full Text PDFForecasting the development of antimicrobial resistance of .
Front Oral Health
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Department of Microbiology, Virology and Immunology, Poltava State Medical University, Poltava, Ukraine.
Unlabelled: Today, about 15.0% of odontogenic pathology is caused by (). The aim of the study was to predict the development of antimicrobial resistance of based on retrospective data.
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