Recent advances have been made in AF treatment, including the role of early rhythm control and landmark clinical trials using ablation therapy. However, some treatment gaps remain, including the creation of durable lesions outside the pulmonary veins and effective treatment of longstanding persistent AF. A novel epicardial-endocardial ablation approach - the hybrid convergent procedure - was developed to combine surgical and catheter ablation techniques into a collaborative, multidisciplinary approach to managing AF. In this review, the authors discuss recently published data on hybrid convergent ablation, including results of the CONVERGE clinical trial, in the context of current challenges to treatment of persistent and long-standing persistent AF. The review also aims to provide perspective on outstanding questions and future directions in this area.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576514 | PMC |
http://dx.doi.org/10.15420/aer.2021.24 | DOI Listing |
Background: Fetal Alcohol Spectrum Disorders (FASD) describes a wide range of neurological defects and craniofacial malformations associated with prenatal ethanol exposure. While there is growing evidence for a genetic component to FASD, little is known of the cellular mechanisms underlying these ethanol-sensitive loci in facial development. Endoderm morphogenesis to form lateral protrusions called pouches is one key mechanism in facial development.
View Article and Find Full Text PDFFEBS J
January 2025
Department of Biological Sciences, Chungnam National University, Daejeon, Korea.
Previous studies have identified three families of knotted phytochrome photoreceptors in cyanobacteria. We describe a fourth type: 'hybrid' phytochromes with putative bilin-binding cysteine residues in both their N-terminal 'knot' extensions and cGMP-phosphodiesterase/adenylate cyclase/FhlA (GAF) domains, which we designate as dual-cysteine bacteriophytochromes (DCBs). Recombinant expression of DCBs in Escherichia coli yields photoactive phycocyanobilin (PCB) adducts with red/far-red photocycles similar to those of the GAF-Cys-containing cyanobacterial phytochromes (Cph1s).
View Article and Find Full Text PDFSensors (Basel)
December 2024
School of Electronics and Information Engineering, Hebei University of Technology, Tianjin 300401, China.
To solve the coverage problem caused by the random deployment of wireless sensor network nodes in the forest fire-monitoring system, a modified marine predator algorithm (MMPA) is proposed. Four modifications have been made based on the standard marine predator algorithm (MPA). Firstly, tent mapping is integrated into the initialization step to improve the searching ability of the early stage.
View Article and Find Full Text PDFAnn Thorac Surg Short Rep
December 2024
Division of Adult Cardiothoracic Surgery, Department of Surgery, University of California, San Francisco, San Francisco, California.
This report presents the case of a 66-year-old man with acute torrential aortic insufficiency after a Ross procedure 20 years earlier, a biologic aortic valve replacement 16 years earlier, and a transcatheter valve-in-valve 4 years earlier. He underwent third-time sternotomy, revealing that the pulmonary autograft was heavily calcified and frozen to the homograft. The previous transcatheter valve-in-valve was explanted.
View Article and Find Full Text PDFElectromagn Biol Med
January 2025
Department of Applied Mathematics, University of Calcutta, Kolkata, India.
The current investigation explores tri-hybrid mediated blood flow through a ciliary annular model, designed to emulate an endoscopic environment. The human circulatory system, driven by the metachronal ciliary waves, is examined in this study to understand how ternary nanoparticles influence wave-like flow dynamics in the presence of interfacial nanolayers. We also analyze the effect of an induced magnetic field on Ag-Cu-/blood flow within the annulus, focusing on thermal radiation, heat sources, buoyancy forces and ciliary motion.
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