Department of Pathology, AIIMS, New Delhi, 110029 India.
Published: November 2021
AI Article Synopsis
Article Abstract
Pulmonary sclerosing pneumocytoma is a rare benign neoplasm of the lung, commonly occurs in middle-aged persons with a marked female predominance. Earlier, it was known as sclerosing hemangioma. Here, we present a case of pulmonary sclerosing pneumocytoma which was diagnosed as carcinoid of the lung, based on imaging, in a 14-year-old female. Besides radiology, the uniqueness of this case lies in the young age (14 years) of the patient. She was presented with a 3.3 × 2.5 × 2.2 cm soft tissue density mass with a tiny speck of calcification in the anterior basal segment of the lower lobe of the right lung. Based on imaging findings on fluorodeoxyglucose positron emission tomography (FDG PET) scan and DOTANOC scan, a diagnosis of carcinoid was made. We performed a video-assisted thoracoscopic right lower lobectomy. Histopathological examination showed features of pulmonary sclerosing pneumocytoma. Surgery is an established method of treatment for pulmonary sclerosing pneumocytoma. Enucleation, lobectomy, sleeve resection are possible treatment options. To define the role of adjuvant therapy, further direct evidence is required. The metastatic potential of this disease is yet to be established.
Pulmonary sclerosing pneumocytoma is a rare benign neoplasm typically seen in middle-aged women. The exact preoperative diagnosis is quite challenging considering its nonspecific clinical and radiologic features along with complex histology. Moreover, obtaining an exact histopathological diagnosis can be difficult especially with the small biopsy specimens.
Pulmonary pneumocytoma, formerly known as sclerosing hemangioma, is a rare, benign tumor that frequently affects women in the 4th and 5th decades of life. Here we present the case of a 17-year-old patient with a diagnosis of sclerosing pneumocytoma with infrequent presentation.
Multiple pulmonary nodules can arise from either benign or malignant processes, with metastasis being a primary concern in patients with a known primary cancer.
Differentiating between the causes of these nodules is complicated, as metastatic nodules can resemble those from infections, inflammation, and rare benign diseases.
Radiological features, along with clinical and laboratory findings, play a crucial role in distinguishing between metastatic and non-metastatic causes of multiple pulmonary nodules, which is essential for accurate diagnosis and treatment.
Objective: To analyze the clinicopathological features and predictors of lymph node metastasis (LNM) in the diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) and compare these findings with conventional papillary thyroid carcinoma (C-PTC) in pediatric populations.
Methods: Patients aged 18 years or younger who were preoperatively diagnosed with PTC and underwent thyroidectomy at the First Affiliated Hospitals of Nanchang University from January 2017 to May 2024 were included in this study. Demographic and clinicopathological characteristics were retrospectively analyzed.
Researchers investigated whether ursodeoxycholic acid (UDCA), used for cholestatic liver diseases, could lower the risk of severe COVID-19 outcomes in patients with primary biliary cholangitis (PBC) or primary sclerosing cholangitis (PSC).
In a population-based study, data from over 11,000 individuals was analyzed, revealing that UDCA users had a 21% lower risk of hospitalization or death from COVID-19 compared to non-users.
The findings warrant further clinical trials to explore UDCA's potential as a preventive treatment for severe COVID-19 outcomes.
