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Excessive iodine can lead to goiters. However, the relationship between the water iodine concentration (WIC) and goiter rate (GR) is unclear. This study aims to explore the factors that influence children's GR in areas with high WIC and analyse the threshold value of the GR increase associated with the WIC. According to the monitoring of the areas with high WIC in China in 2018-2020, a total of 54 050 children in eight high water iodine provinces were chosen. Drinking water, urine and edible salt samples of children were collected. The thyroid volume (Tvol) was measured. A generalised additive model (GAM) was used to analyse the relationship between the WIC and GR in children. Among the 54 050 children in areas with high WIC, the overall GR was 3·34 %, the median of water iodine concentration was 127·0 µg/l, the median of urinary iodine concentration was 318 µg/l and the non-iodised salt coverage rate (NISCR) was 63·51 %. According to the GAM analysis results, water iodine and urinary iodine are factors that influence the Tvol and GR, while the NISCR affects only the GR. When the WIC was more than 420 µg/l or the urinary iodine concentration was more than 800 µg/l, the GR increased rapidly. When the NISCR reached more than 85 %, the GR was the lowest. Thus, in areas with high WIC, WIC more than 420 µg/l may increase the risk of goiter, and the NISCR should be increased to over 85 % to avoid goiters in children.
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http://dx.doi.org/10.1017/S0007114521004529 | DOI Listing |
Diagn Microbiol Infect Dis
March 2025
School of Medical Laboratory Science, Jimma University, Jimma, Ethiopia. Electronic address:
Background: Human Immunodeficiency Viruses (HIV) infected people are at increased chance of immunocompromission. In combination with this immunocompromission, the incidence of co-infection with intestinal parasites, intestinal protozoal and Helicobacter pylori can be escalated by different factors including similar mode of transmission, poor economic status, synergistic pathogenesis, and geographic topography of more than two organisms. A large number of world population is either affected or at risk of infection from diversified intestinal parasites, intestinal protozoal and H.
View Article and Find Full Text PDFJ Fish Biol
March 2025
Guangdong Provincial Water Environment and Aquatic Products Security Engineering Technology Research Center, Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
Gut microbiota stability is crucial for maintaining fish health. In aquaculture, antibiotics and disinfectants are frequently used to manipulate the host gut microbiota, but the combined effects on asymptomatic fish remain unclear. We investigated the effects of single and combined treatments with antibiotics and disinfectants on grass carp (Ctenopharyngodon idella) gut health, immune response, microbiome dynamics and transcriptome profile.
View Article and Find Full Text PDFFront Vet Sci
February 2025
Business Innovation Department, Furukawa Sangyo Kaisha, Ltd., Tokyo, Japan.
Disinfection is crucial for preventing surgical site infections. Recently, the effectiveness of sanitizers using chlorous acid (HClO) under conditions rich in organic matter has been reported, and chlorous acid water (CAW) has been approved as a food additive. This study evaluated the potential of CAW as a new presurgical disinfectant for cattle.
View Article and Find Full Text PDFEnviron Res
March 2025
School of Chemistry and Chemical Engineering/Key Laboratory of Environmental Monitoring and Pollutant Control, Shihezi University, Shihezi. 832003, PR China. Electronic address:
Iodine plays a key role in atmospheric chemistry that can significantly affect the atmospheric oxidation capacity. Although the oceans are the main reservoir of iodine on Earth, iodine is also widely present in the terrestrial environment. Therefore, a comprehensive understanding of the present sources of iodine in inland areas is warranted for the evaluation of its environmental effect.
View Article and Find Full Text PDFMed Chem
March 2025
Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of RAS, Lavrentiev Ave. 8, 630090 Novosibirsk, Russia.
Introduction: Nowadays, use of phosphate modifications in oligonucleotide backbone has become a common approach for imbuing its structure with the desired beneficial properties. The recent advances in successful application of different classes of phosphate modifications in the design of therapeutic oligonucleotides have led to a renewed interest in the development of approaches for introducing diverse classes of phosphate modifications.
Methods: This study aims to investigate the efficiency and optimize protocols for the application of the iodine-amine oxidation reaction to produce various N-alkyl phosphoramidate oligonucleotide derivatives during the conventional solid-phase phosphoramidite synthesis method.
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