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Probiotics Exert Gut Immunomodulatory Effects by Regulating the Expression of Host miRNAs.
Probiotics Antimicrob Proteins
January 2025
Department of Reproductive Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Probiotics exert a diverse range of immunomodulatory effects on the human gut immune system. These mechanisms encompass strengthening the intestinal mucosal barrier, inhibiting pathogen adhesion and colonization, stimulating immune modulation, and fostering the production of beneficial substances. As a result, probiotics hold significant potential in the prevention and treatment of various conditions, including inflammatory bowel disease and colorectal cancer.
View Article and Find Full Text PDFEvolution of competitive ability and the response to nutrient availability: a resurrection study with the calcareous grassland herb, Leontodon hispidus.
Oecologia
January 2025
Plant Evolutionary Ecology, Institute of Ecology, Evolution and Diversity, Faculty of Biological Sciences, Goethe University Frankfurt, Max-Von-Laue-Str. 13, 60438, Frankfurt am Main, Germany.
Rapid environmental changes across Europe include warmer and increasingly variable temperatures, changes in soil nutrient availability, and pollinator decline. These abiotic and biotic changes can affect natural plant populations and force them to optimize resource use against competitors. To date, the evolution of competitive ability in the context of changes in nutrient availability remains understudied.
View Article and Find Full Text PDFApical periodontitis microbiome association with salivary and serum inflammatory burden.
Int Endod J
January 2025
Department of Endodontics, Centre of Oral Clinical and Translational Sciences, Faculty of Dentistry, Oral and Craniofacial Sciences, Guy's Dental Hospital, King's College London, London, UK.
Aims: Apical Periodontitis (AP) involves complex interactions between the root canal microbiome and the host immune response, with potential risk of local and systemic inflammatory burden, however there is no evidence available regarding correlation between microbiome and inflammatory marker levels. This study aims to identify the microbiome of saliva, intracanal and blood samples in AP subjects and investigate the correlation between intracanal and blood microbiomes with serum inflammatory biomarker levels, and salivary microbiomes with salivary inflammatory biomarker levels.
Methodology: Saliva, Intracanal and blood samples were collected from AP patients undergoing root canal retreatment.
Providers' Beliefs and Values: Understanding Their Approach to Gender-Affirming Care.
J Prim Care Community Health
January 2025
University of Rochester, Rochester, NY, USA.
Objectives: This qualitative study explored the beliefs and values influencing healthcare providers' delivery of gender-affirming care (GAC) to transgender and gender-diverse (TGD) youth amidst current social and political dynamics.
Methods: The study PI conducted 43 semi-structured interviews with providers across states with varying GAC legislation. Responses from 41 providers were analyzed in this paper.
Contextualizing Psychological First Aid for the Pacific Island Countries.
Australas Psychiatry
January 2025
College of Asia Pacific Studies, Ritsumeikan Asia Pacific University, Oita, Japan.
Objective: This article explores the views towards contextualizing Psychological First Aid (PFA) to address the specific needs of communities in Pacific Island Countries (PICs) impacted by disasters. The methodological approach involved a review of existing literature on PFA's relevance, adaptation, and effectiveness in disaster response settings.
Findings: In disaster response, PFA is a recognized, evidence-informed psychosocial support activity internationally, yet measuring its effectiveness in real-time disasters remains challenging.
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