Siliceous fly ash (FA) is the main additive to currently produced concretes. The utilization of this industrial waste carries an evident pro-ecological factor. In addition, such actions have a positive effect on the structure and mechanical parameters of mature concrete. Unfortunately, the problem of using FA as a Portland cement replacement is that it significantly reduces the performance of concretes in the early stages of their curing. This limits the possibility of using this type of concrete, e.g., in prefabrication, where it is required to obtain high-strength composites after short periods of curing. In order to minimize these negative effects, this research was undertaken to increase the early strength of concretes with FA through the application of a specifically formulated chemical nano-admixture (NA) in the form of seeds of the C-S-H phase. The NA was used to accelerate the strength growth in concretes. Therefore, this paper presents results of tests of modified concretes both with the addition of FA and with innovative NA. The analyses were carried out based on the results of the macroscopic and microstructural tests in five time periods, i.e., after 4, 8, 12, 24 and 72 h. The results of tests carried out with the use of NA clearly indicate the possibility of using FA in a wide range of management areas in sustainable concrete prefabrication.
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http://dx.doi.org/10.3390/ma14216514 | DOI Listing |
N Engl J Med
December 2024
From Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York (K.L.J.); University Hospitals Leuven, Leuven, Belgium (P.N.); Hospital María Curie, Buenos Aires (M.L.C.); Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (S.-B.K.); National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan (E.T.); Institut Jules Bordet, Hôpital Universitaire de Bruxelles, Brussels (P.A.); Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology, Barcelona (C.S.); Baylor University Medical Center, Texas Oncology, U.S. Oncology, Dallas (J.O.); the Breast Center, Department of Obstetrics and Gynecology and Comprehensive Cancer Center Munich, Ludwig Maximilians University Munich University Hospital, Munich, Germany (N.H.); the University of North Carolina at Chapel Hill, Chapel Hill (L.A.C.); the University of Milan, Milan (G.C.); the European Institute of Oncology, IRCCS, Milan (G.C.); Hospital Arnau de Vilanova, Valencia, Spain (A.L.-C.); Garvan Institute of Medical Research and University of New South Wales, Sydney (E.L.); Hospital de Oncología, Centro Médico Nacional Siglo XXI, Mexico City (M.L.G.T.); Yonsei University College of Medicine, Seoul, South Korea (J.S.); the Mastology Department, Women's Health Hospital, São Paulo (A.M.); Harbin Medical University Cancer Hospital, Harbin, China (Q.Z.); National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei (C.-S.H.); the Division of Breast Surgery, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan (C.-C.H.); Filios Alta Medicina, Monterrey, Mexico (J.L.M.R.); the Medical Oncology Department, Hospital Universitario Virgen del Rocío, Seville, Spain (M.R.B.); the Department of Breast Surgery, Chiba Cancer Center Hospital, Chiba, Japan (R.N.); Eli Lilly, Indianapolis (K.R.P., C.C.L., E.B., S.C., X.A.W., L.M.S.); and Institut Curie and University of Versailles Saint-Quentin-en-Yvelines-Paris-Saclay University, Paris (F.-C.B.).
Background: Imlunestrant is a next-generation, brain-penetrant, oral selective estrogen-receptor (ER) degrader that delivers continuous ER inhibition, even in cancers with mutations in the gene encoding ERα ().
Methods: In a phase 3, open-label trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer that recurred or progressed during or after aromatase inhibitor therapy, administered alone or with a cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Patients were assigned in a 1:1:1 ratio to receive imlunestrant, standard endocrine monotherapy, or imlunestrant-abemaciclib.
Mol Ther
November 2024
Laboratory of Stem Cell & Neurobiology, Department of Oral Anatomy and Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Republic of Korea; Interdisciplinary Program in Neuroscience, Seoul National University College of Natural Sciences, Seoul 08826, Republic of Korea; Neuroscience Research Institute, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:
RSC Adv
November 2024
Dipartimento per lo Sviluppo Sostenibile e la Transizione Ecologica, Università del Piemonte Orientale A. Avogadro piazza S. Eusebio 5 13100 Vercelli Italy
The rice husk biomass remaining from the industrial processing of rice constitutes approximately 25 wt% of the edible rice produced, and its disposal is challenging due to its high silica content. Here, we describe the optimization of a single step innovative chemical process for the conversion of rice husk-based biomass into useable products which tackles all fractions of the input biomass. The chemical process consists of a single step hydrothermal low temperature treatment of rice husk biomass leading to three easy-to-recover fractions.
View Article and Find Full Text PDFSci Total Environ
December 2024
Materials Science and Engineering, Faculty of Engineering, Hokkaido University, Kita 13, Nishi 8, Kita-ku, Sapporo 060-8628, Japan.
The escalating issue of global warming, driven by the surge in CO emissions, necessitates innovative strategies for reducing CO emissions. A novel approach is explored in this study, where amines featuring a basic N atom with a lone pair are incorporated into cement paste to facilitate CO capture from the environment. Unlike conventional applications, the focus is on the collaborative effect of various amines on CO capture within diverse calcium-rich phases, encompassing portlandite and Calcium-Silicate-Hydrate (C-S-H).
View Article and Find Full Text PDFMaterials (Basel)
October 2024
Department of Metallurgical and Materials Engineering, Marmara University, 34722 Istanbul, Turkey.
This study reports an alkali-activated binder including blast furnace slag (BFS) together with marble waste (MW). Cement is an industrial product that emits a significant amount of CO during its production and incurs high energy costs. MW is generated during the extraction, cutting, and processing of marble in production facilities, where dust mixes with water to form a settling sludge.
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