AI Article Synopsis
- Trisomic individuals can help map genes to centromeres because their meiotic tetrads have extra chromatids.
- When centromeric markers are used, researchers can analyze genetic linkage in families with trisomic children.
- A new FORTRAN program called DSLINK allows for this analysis, incorporating data from both trisomic and disomic offspring to explore recombination and chromosome segregation relationships.
Article Abstract
Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684185 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!