AI Article Synopsis
- - The cause of Alzheimer's disease (AD) is not well understood, and there is currently no effective cure or treatment to halt its progression.
- - The study explored the therapeutic potential of ramalin, a compound derived from Antarctic lichen, for treating AD, highlighting its antioxidant, BACE-1 inhibition, and anti-inflammatory properties.
- - Ramalin and its synthesized derivatives show promise as potential treatments by targeting multiple pathways related to Alzheimer's disease.
Article Abstract
The pathogenesis of Alzheimer's disease (AD) is still unclear, and presently there is no cure for the disease that can be used for its treatment or to stop its progression. Here, we investigated the therapeutic potential of ramalin (isolated from the Antarctic lichen, ), which exhibits various physiological activities, in AD. Specifically, derivatives were synthesized based on the structure of ramalin, which has a strong antioxidant effect, BACE-1 inhibition activity, and anti-inflammatory effects. Therefore, ramalin and its derivatives exhibit activity against multiple targets associated with AD and can serve as potential therapeutic agents for the disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8588271 | PMC |
| http://dx.doi.org/10.3390/molecules26216445 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!