The power of machine learning (ML) in feature identification can be harnessed for determining quantities in experiments that are difficult to measure directly. However, if an ML model is trained on simulated data, rather than experimental results, the differences between the two can pose an obstacle to reliable data extraction. Here we report on the development of ML-based diagnostics for experiments on high-intensity laser-matter interactions. With the intention to accentuate robust, physics-governed features, the presence of which is tolerant to such differences, we test the application of principal component analysis, data augmentation and training with data that has superimposed noise of gradually increasing amplitude. Using synthetic data of simulated experiments, we identify that the approach based on the noise of increasing amplitude yields the most accurate ML models and thus is likely to be useful in similar projects on ML-based diagnostics.
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http://dx.doi.org/10.3390/s21216982 | DOI Listing |
Sci Rep
January 2025
Department of Urology, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu, 241001, Anhui, People's Republic of China.
To create a diagnostic tool before biopsy for patients with prostate-specific antigen (PSA) levels < 20 ng/ml to minimize prostate biopsy-related discomfort and risks. Data from 655 patients who underwent transperineal prostate biopsy at the First Affiliated Hospital of Wannan Medical College from July 2021 to January 2023 were collected and analyzed. After applying the Synthetic Minority Over-sampling TEchnique class balancing on the training set, multiple machine learning models were constructed by using the Least Absolute Shrinkage and Selection Operator (LASSO) feature selection to identify the significant variables.
View Article and Find Full Text PDFBackground: Primary progressive aphasia (PPA) is a language-based dementia linked with underlying Alzheimer's disease (AD) or frontotemporal dementia. Clinicians often report difficulty differentiating between the logopenic (lv) and nonfluent/agrammatic (nfv) subtypes, as both variants present with disruptions to "fluency" yet for different underlying reasons. In English, acoustic and linguistic markers from connected speech samples have shown promise in machine learning (ML)-based differentiation of nfv from lv.
View Article and Find Full Text PDFBackground: Primary progressive aphasia (PPA) is a language-led dementia associated with underlying Alzheimer's disease (AD) or frontotemporal lobar degeneration pathology. As part of the Alzheimer's spectrum, logopenic (lv) PPA may be particularly difficult to distinguish from amnestic AD, due to overlapping clinical features. Analysis of linguistic and acoustic variables derived from connected speech has shown promise as a diagnostic tool for differentiating dementia subtypes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of California, Davis, Sacramento, CA, USA.
Background: Microinfarcts, characteristic lesions of vascular dementia (VaD), are heterogenous and vary in appearance, which pose a considerable challenge for VaD grading as there is great interrater variability in microinfarct assessment. We propose a novel application of machine learning (ML) in the automated screening of microinfarcts, addressing a gap in the post-mortem analysis of VaD in whole slide images (WSIs) from human brain.
Method: Our study adapts a patch-based pipeline with convolutional neural networks (CNNs) to automate microinfarct screening in WSIs.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Introduction: Over 9 million Americans are projected to have dementia by 2030, and adults with mild cognitive impairment (MCI), a potential pre-cursor to dementia, will also rise. With recent and emerging clinical trial evidence for interventions to slow the progression of MCI to dementia, identification of persons in primary care with undiagnosed early-stage cognitive impairment may provide opportunity for preventive intervention.
Methods: A Machine Learning (ML)-based prediction model trained using data from the electronic health record was applied to patients without formal diagnoses of cognitive impairment who were currently seen in selected primary care practices.
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