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Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused. | LitMetric

Monoclonal Antibodies against SARS-CoV-2: Potential Game-Changer Still Underused.

Int J Environ Res Public Health

Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.

Published: October 2021

AI Article Synopsis

  • Despite a large vaccination effort, COVID-19 mortality and hospital admissions remain high, especially among patients over 70 years old.* -
  • In Italy, only 9% of infected individuals in this age group received monoclonal antibody treatment, which could have significantly reduced hospital admissions and deaths if used more broadly.* -
  • A hypothetical increase in monoclonal antibody use could have led to substantial financial savings for the healthcare system, with estimates of over USD 117 million saved.*

Article Abstract

Even several months after the start of a massive vaccination campaign against COVID-19, mortality and hospital admission are still high in many countries. Monoclonal antibodies against SARS-CoV-2 are the ideal complement to vaccination in infected subjects who are at high risk for progression to severe disease. Based on data of the Italian Ministry of Health, in the period April-August 2021, monoclonal antibodies were prescribed to 6322 patients. In the same period, 70,022 patients over 70 years old became infected with SARS-CoV-2. Even considering that all monoclonal antibodies were prescribed to this category of patients, we calculated that only 9% of these subjects received the treatment. Moreover, using efficacy data provided by clinal trials, we estimated the potential benefit in terms of reduction of hospital admissions and deaths. Considering utilisation of monoclonal antibodies in half infected patients over 70 years, we estimated that hospital admissions and deaths might have been reduced by 7666 and 3507, respectively. Finally, we calculated the economic benefit of monoclonal use. In the same scenario (50% use of monoclonal antibodies to patients over 70), we estimated potential savings of USD 117,410,105. In conclusion, monoclonal antibodies were used in a small proportion of patients over 70 in Italy. A more extensive use might have resulted in a marked decrease in hospital admissions, deaths and in conspicuous saving for the health system.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583134PMC
http://dx.doi.org/10.3390/ijerph182111159DOI Listing

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