AI Article Synopsis
- Nano-sized zinc oxide (nano-ZnO) impacts lipid metabolism and absorption mechanisms in yellow catfish, with significant findings about how it affects intestinal tissue.
- The study revealed that high doses (100 mg/kg) of nano-ZnO increased zinc levels and affected the expression of several key mRNAs linked to lipid metabolism.
- It was observed that nano-ZnO enhances triglyceride levels and the activity of enzymes involved in fat production, while also indicating that its absorption in intestinal cells occurs through endocytosis, tied to a novel signaling pathway involving the metal responsive transcription factor 1 (MTF-1) and small heterodimer partner (SHP).
Article Abstract
Nano-sized zinc oxide (nano-ZnO) affects lipid deposition, but its absorption patterns and mechanisms affecting lipid metabolism are still unclear. This study was undertaken to investigate the molecular mechanism of nano-ZnO absorption and its effects on lipid metabolism in the intestinal tissues of a widely distributed freshwater teleost yellow catfish . We found that 100 mg/kg dietary nano-ZnO (H-Zn group) significantly increased intestinal Zn contents. The and mRNA expression levels were higher in the H-Zn group than those in the control (0 mg/kg nano-ZnO), and mRNA abundances were higher in the control than those in the L-Zn (50 mg/kg nano-ZnO) and H-Zn groups. Eps15, , , and mRNA expression levels tended to reduce with dietary nano-ZnO addition. Dietary nano-ZnO increased triglyceride (TG) content and the activities of the lipogenic enzymes glucose 6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), and isocitrate dehydrogenase (ICDH), upregulated the mRNA abundances of lipogenic genes , and , and reduced the mRNA expression of and small heterodimer partner (). The SHP protein level in the H-Zn group was lower than that in the control and the L-Zn group markedly. Our in vitro study indicated that the intestinal epithelial cells (IECs) absorbed nano-ZnO via endocytosis, and nano-Zn-induced TG deposition and lipogenesis were partially attributable to the endocytosis of nano-ZnO in IECs. Mechanistically, nano-ZnO-induced TG deposition was closely related to the metal responsive transcription factor 1 (MTF-1)-SHP pathway. Thus, for the first time, we found that the lipogenesis effects of nano-ZnO probably depended on the key gene which is potentially regulated by MTF1 and/or FXR. This novel signaling pathway of MTF-1 through SHP may be relevant to explain the toxic effects and lipotoxicity ascribed to dietary nano-ZnO addition.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584588 | PMC |
| http://dx.doi.org/10.3390/ijms222112047 | DOI Listing |
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