AI Article Synopsis
- BMPs are growth factors from the TGF-β superfamily that initially promoted bone formation but are now known to regulate the development of the female reproductive system.
- BMPs are crucial for the differentiation of human pluripotent stem cells into reproductive tissues, highlighting their importance in reproductive health.
- The review aims to summarize BMP signaling in the female reproductive system and its potential for developing therapies for related diseases.
Article Abstract
Bone morphogenetic proteins (BMPs) are a group of multifunctional growth factors that belong to the transforming growth factor-β (TGF-β) superfamily of proteins. Originally identified by their ability to induce bone formation, they are now known as essential signaling molecules that regulate the development and function of the female reproductive system (FRS). Several BMPs play key roles in aspects of reproductive system development. BMPs have also been described to be involved in the differentiation of human pluripotent stem cells (hPSCs) into reproductive system tissues or organoids. The role of BMPs in the reproductive system is still poorly understood and the use of FRS tissue or organoids generated from hPSCs would provide a powerful tool for the study of FRS development and the generation of new therapeutic perspectives for the treatment of FRS diseases. Therefore, the aim of this review is to summarize the current knowledge about BMP signaling in FRS development and function.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584982 | PMC |
| http://dx.doi.org/10.3390/ijms222111927 | DOI Listing |
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