Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up.

Unlabelled: To date, inconsistent results evaluating the effect of parameters on mechanical thrombectomy (MT) outcomes in stroke-patients have been published. This study aimed to identify the key parameters for functional status after MT in stroke-patients in short and long-term follow-up.

Method: The study analysis focused on the relevance of selected clinical and non-clinical parameters to the functional status of the patients after MT.

Results: 417 stroke-patients (mean age 67.8 ± 13.2 years) were qualified. Atrial fibrillation, and leukocytosis were significant for the neurological status on the first day of stroke ( = 0.036, and = 0.0004, respectively). The parameters with the strongest effect on the functional status on day 10 were: age ( = 0.009), NIHSS ( = 0.002), hyperglycemia ( = 0.009), the result in TICI ( = 0.046), and first pass effect ( = 0.043). The parameters with the strongest effect on the functional status on day 365 were: age and NIHSS on the first day of stroke ( = 0.0002 and 0.002, respectively). Leukocytosis and the neurological status at baseline were key parameters associated with ICB after MT ( = 0.007 and = 0.003, respectively).

Conclusions: Age and neurological status in the ultra-acute phase of stroke are crucial for the functional status in short and long-term observations of patients treated with mechanical thrombectomy. Atrial fibrillation, hyperglycemia, and inflammatory state are relevant to the short-term post-stroke functional status. First pass effect and the degree of post-interventional reperfusion are important technical parameters to the short-term functional status. Neurological status and white blood count during the acute phase are associated with a high rate of post-procedural intracranial bleeding.