Several studies have linked apical periodontitis and systemic diseases. The aim of this study is to present a systematic review of the available literature investigating whether there is an association between pulpal-periapical pathology and autoimmune disease. The review was conducted following the PRISMA statement. A literature search was performed in five databases. Studies involving patients with pulpal-periapical pathology and autoimmune diseases were included in the review. Based on the PICO model, the research question aimed to assess whether there is an increased risk of developing pulpal-periapical pathology in patients with autoimmune disease. Article selection, data extraction, and quality assessment were performed using an adapted version of the STROBE guidelines. A total of seven studies were included in our review. The types of articles were five case-control and two cross-sectional studies. Periapical pathologies were associated to three autoimmune diseases (diabetes mellitus I, rheumatoid arthritis, and inflammatory bowel disease). Among the included studies, four show a low risk of bias, while three present a moderate risk. There could be an association between apical periodontitis and autoimmune diseases, although most studies report statistically non-significant associations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584450 | PMC |
| http://dx.doi.org/10.3390/jcm10214886 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between rheumatoid arthritis and pulpal-periapical pathology: a systematic review.
Clin Oral Investig
December 2023
Periodontology Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Objectives: Rheumatoid arthritis (RA) is a debilitating disease where numerous pro-inflammatory cytokines have a proven role in its pathology. These cytokines are also involved in the pathogenesis of apical periodontitis (AP) where they have a pro-inflammatory role and induce bone resorption. Patients with RA may therefore be more prone to develop pulpal-periapical pathology (PPP).
View Article and Find Full Text PDFClinical and radiographic features of external cervical resorption - An observational study.
Int Endod J
December 2023
Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, UK.
Aim: To determine the prevalence of symptoms, clinical signs and radiographic presentation of external cervical resorption (ECR).
Methodology: This study involved 215 ECR lesions in 194 patients referred to the Endodontic postgraduate Unit at King's College London or Specialist Endodontic practice (London, UK). The clinical and radiographic findings (periapical [PA] and cone beam computed tomography [CBCT]) were readily accessible for evaluation.
Association between Pulpal-Periapical Pathology and Autoimmune Diseases: A Systematic Review.
J Clin Med
October 2021
Special Care Dentistry and Gerodontology Unit, School of Medicine and Dentistry, IMIB-Arrixaca, University of Murcia, 30100 Murcia, Spain.
Several studies have linked apical periodontitis and systemic diseases. The aim of this study is to present a systematic review of the available literature investigating whether there is an association between pulpal-periapical pathology and autoimmune disease. The review was conducted following the PRISMA statement.
View Article and Find Full Text PDFPreventive endodontics by direct pulp capping with restorative dentin substitute-biodentine: A series of fifteen cases.
Indian J Dent Res
December 2018
Department of Conservative Dentistry and Endodontics, Hitkarini Dental College and Hospital, Jabalpur, Madhya Pradesh, India.
Introduction: Treatment of mechanical exposure of the pulp during caries excavation presents a clinical challenge. In this case series of 15 patients, with a follow-up period of over a year, the outcome of direct pulp capping with Biodentine (septodont) after mechanical pulp exposure was assessed.
Aim Of Study: The aim of this study is to evaluate the outcome of direct pulp capping with Biodentine in deeply carious teeth when pulp was mechanically exposed during caries excavation and cavity preparation.
Role of mast cells in inflammatory and reactive pathologies of pulp, periapical area and periodontium.
J Oral Maxillofac Pathol
January 2018
Departments of Oral and Maxillofacial Pathology, V S Dental College and Hospital, Bengaluru, Karnataka, India.
Mast cells (MCs) have been discovered over 130 years ago; their function was almost exclusively linked to allergic affections. At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions. In the oral tissues, MCs release different pro-inflammatory cytokines and tumor necrosis factor-alpha that promote leukocyte infiltration in various inflammatory states of the oral cavity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!