We analyze four-dimensional Friedmann-Lemaître-Robertson-Walker cosmologies in type IIB, arising from a M-theory dual, and find that the null energy condition (NEC) has to be obeyed by them (except for the negatively curved case) in order for the M-theory action to have a Wilsonian effective description. However, this does not imply that the M-theory metric has to obey the 11D NEC. Thus, we propose a new swampland conjecture-the 4D NEC is a consistency condition for any theory to have a completion within M theory-with an explicit derivation of it for cosmological backgrounds from a top-down perspective. We briefly discuss the cosmological consequences of such a condition derived from M theory.
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Nutrients
December 2024
Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.
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View Article and Find Full Text PDFWaste Manag Res
December 2024
Chair of Waste Processing Technology and Waste Management, Department of Environmental and Energy Process Engineering, Montanuniversitaet Leoben, Leoben, Austria.
This article uses model materials to introduce a controlled, location- and manufacturer-independent internationally accepted method for assessing shredding machines based on large-scale tests. Furthermore, a better understanding of the comminution behaviour of shredders with fixed settings (gap width, shaft speed, cutting tool geometry) is in the focus of the present investigation and assessed, using the statistical analyses for particle size distribution in certain screen sections. Conclusions have been drawn on the comminution behaviour in general and the material-material interactions of different fractions in the grinding chamber of the shredder by showing significant differences in the pure fraction's comminution behaviour against the mixture's comminution behaviour.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Group of Characterization of Materials, Departament de Física, Universitat Politècnica de Catalunya, Campus Diagonal-Besòs, Av. Eduard Maristany 10-14, Barcelona 08019, Spain.
Hybrid organic-inorganic perovskites (HOIP) have emerged in recent years as highly promising semiconducting materials for a wide range of optoelectronic and energy applications. Nevertheless, the rotational dynamics of the organic components and many-molecule interdependencies, which may strongly impact the functional properties of HOIP, are not yet fully understood. In this study, we quantitatively analyze the orientational disorder and molecular correlations in archetypal perovskite CHNHPbI (MAPI) by performing comprehensive molecular dynamics simulations and entropy calculations.
View Article and Find Full Text PDFWorld J Exp Med
December 2024
Department of Internal Medicine, Gayatri Vidya Parishad Institute of Healthcare and Medical Technology, Visakhapatnam 530048, Andhra Pradesh, India.
Obesity is increasingly prevalent worldwide, with genetic factors contributing to its development. The hypothalamic leptin-melanocortin pathway is central to the regulation of appetite and weight; leptin activates the proopiomelanocortin neurons, leading to the production of melanocortin peptides; these in turn act on melanocortin 4 receptors (MC4R) which suppress appetite and increase energy expenditure. MC4R mutations are responsible for syndromic and non-syndromic obesity.
View Article and Find Full Text PDFBrain Behav Immun
December 2024
Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph ON, Canada. Electronic address:
Chronic pain is a major global concern, with at least 1 in 5 people suffering from chronic pain worldwide. Mounting evidence indicates that neuroplasticity of the anterior cingulate cortex (ACC) is a critical step in the development of chronic pain. Previously, we found that chronic pain and fear learning are both associated with enhanced neuronal excitability and cause similar neuroplasticity-related gene expression changes in the ACC of male mice.
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