AI Article Synopsis
- Osteocytes play a key role in the process of bone remodeling when exposed to unloading conditions, making them crucial for understanding changes in bone health during space missions.
- Researchers often use animal models and in vitro systems instead of human bone biopsies to study these effects in both microgravity and simulated conditions on Earth.
- The review examines how osteocytes influence bone mass changes and the activity of other bone cells, while also questioning the roles of signaling molecules and discussing how microgravity affects fluid flow and mechanical stress on bones.
Article Abstract
Purpose Of Review: Osteocytes are considered to be the cells responsible for mastering the remodeling process that follows the exposure to unloading conditions. Given the invasiveness of bone biopsies in humans, both rodents and in vitro culture systems are largely adopted as models for studies in space missions or in simulated microgravity conditions models on Earth.
Recent Findings: After a brief recall of the main changes in bone mass and osteoclastic and osteoblastic activities in space-related models, this review focuses on the potential role of osteocytes in directing these changes. The role of the best-known signalling molecules is questioned, in particular in relation to osteocyte apoptosis. The mechanotransduction actors identified in spatial conditions and the problems related to fluid flow and shear stress changes, probably enhanced by the alteration in fluid flow and lack of convection during spaceflight, are recalled and discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716347 | PMC |
| http://dx.doi.org/10.1007/s11914-021-00713-8 | DOI Listing |
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