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Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection? | LitMetric

AI Article Synopsis

  • Immunoglobulin E (IgE) helps protect mammals from parasites and toxins and is important for allergies.
  • While IgE is used to diagnose allergies, it's not often used to diagnose parasitic infections, even though it could be helpful.
  • Researchers are working on new ways to use IgE for parasite diagnosis but need to be careful about which allergens they use for testing.

Article Abstract

Immunoglobulin E (IgE) is thought to have evolved to protect mammalian hosts against parasitic infections or toxins and plays a central role in the pathogenesis, diagnosis, and therapy of IgE-mediated allergy. Despite the prominence of IgE responses in most parasitic infections, and in stark contrast to its use in the diagnosis of allergy, this isotype is almost completely unexploited for parasite diagnosis. Here, we discuss the perceived or real limitations of IgE-based diagnosis in parasitology and suggest that the recent creation of a new generation of very sensitive cellular IgE-based reporters may represent a powerful new diagnostic platform, but needs to be based on a very careful choice of diagnostic allergens.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986668PMC
http://dx.doi.org/10.1007/s00436-021-07352-zDOI Listing

Publication Analysis

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