AI Article Synopsis
- The study explores how the hydrogen-bonded structure of water affects the biocompatibility of polymers, particularly loop-shaped poly(ethylene glycol) chains.
- Using synchrotron soft X-ray emission spectroscopy, researchers identified changes in the water structure based on the density of anchoring molecules within the polymer.
- Findings suggest that the confined water lacks a specific energy peak due to spatial constraints, indicating that tuning the anchoring density can control both the characteristics of the water and the biocompatibility of the polymers.
Article Abstract
Hydrogen-bonded network of water surrounding polymers is expected to be one of the most relevant factors affecting biocompatibility, while the specific hydrogen-bonded structure of water responsible for biocompatibility is still under debate. Here we study the hydrogen-bonded structure of water in a loop-shaped poly(ethylene glycol) chain in a polyrotaxane using synchrotron soft X-ray emission spectroscopy. By changing the density of anchoring molecules, hydrogen-bonded structure of water confined in the poly(ethylene glycol) loop was identified. The XES profile of the confined water indicates the absence of the low energy lone-pair peak, probably because the limited space of the polymer loop entropically inhibits the formation of tetrahedrally coordinated water. The volume of the confined water can be changed by the anchoring density, which implies the ability to control the biocompatibility of loop-shaped polymers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8577270 | PMC |
| http://dx.doi.org/10.3389/fchem.2021.743255 | DOI Listing |
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