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Galegine, a Bioprivileged Alkaloid from Tithonia tubaeformis: Antipyretic Activity Insights.
Curr Top Med Chem
January 2025
Department of Chemistry, University of Swabi, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
Background: In continuation of our chemical and biological work on Tithonia tubaeformis, we evaluated the antipyretic activity of its extract which on fractionation gives a pure alkaloid galegine. Galegine a bioprivileged compound, is a hemiterpene bearing a guanidine group, which holds significant importance in medicinal chemistry. Biological activities such as antimicrobial, antidiabetic, anti-inflammatory, cardiovascular, anticancer, and antihypertensive, are often associated with guanidine-containing molecules.
View Article and Find Full Text PDFQuantitative Analysis of Temporomandibular Joint Adaptations After One Year of Complete Denture Use: A Cone-Beam Computed Tomography Study.
Cureus
December 2024
Department of Prosthodontics and Crown and Bridge, Kothiwal Dental College and Research Centre, Moradabad, IND.
Introduction: Alterations in occlusal relationships in individuals with complete edentulism considerably disrupt the equilibrium of the stomatognathic system. Evaluation of the temporomandibular joint (TMJ) is crucial during the edentulous phase, as it influences both aesthetic and functional outcomes. This investigation sought to assess alterations in condylar positioning one year after the placement of complete dentures in edentulous patients, with additional objectives to examine variations based on sex and side.
View Article and Find Full Text PDFPotato is a versatile food crop and major component of human nutrition worldwide. Model calculations and computer simulations can be used to optimize the resource allocation in potato breeding programs but require quantitative genetic parameters. The objectives of our study are to (i) estimate quantitative genetic parameters of the most important phenotypic traits in potato breeding programs, (ii) compare the importance of inter- vs.
View Article and Find Full Text PDFA CONVEX COMPRESSIBILITY-INSPIRED UNSUPERVISED LOSS FUNCTION FOR PHYSICS-DRIVEN DEEP LEARNING RECONSTRUCTION.
Proc IEEE Int Symp Biomed Imaging
May 2024
Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Physics-driven deep learning (PD-DL) methods have gained popularity for improved reconstruction of fast MRI scans. Though supervised learning has been used in early works, there has been a recent interest in unsupervised learning methods for training PD-DL. In this work, we take inspiration from statistical image processing and compressed sensing (CS), and propose a novel convex loss function as an alternative learning strategy.
View Article and Find Full Text PDFExploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations.
Front Chem
January 2025
Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections represent critical global health challenges due to the high morbidity and mortality associated with co-infections. HIV, the causative agent of acquired immunodeficiency syndrome (AIDS), infects 4,000 people daily, potentially leading to 1.2 million new cases by 2025, while HCV chronically affects 58 million people, causing cirrhosis and hepatocellular carcinoma.
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