Phytochemical profile and antiproliferative activities of acetone extracts of Blume. and Hook. in MDA-MB-231 breast cancer cells.

The plants extracts are widely used in traditional medicines and hence considered a potential source for drug discovery. In this study, we assessed the phytochemical composition of and in acetone extracts and checked its antiproliferative potential in MDA-MB-231 cells. We found that both plants are rich in phenolic and flavonoid compounds and are efficient in antioxidant activities. The total phenolic compounds in were 44.15 ± 1.38 µg/mg whereas in were 27.73 ± 1.35 µg/mg. Total flavonoids in were 105.39 ± 2.92 µg/mg whereas in were 101.56 ± 1.75 µg/mg. The ferric reducing power assay indicates 66.38 ± 2.6% reduction by whereas 78.43 ± 0.47% reduction by Similarly, the total antioxidant capacity of was found to be 59.95 ± 1.13 whereas for the recorded value was 33.03 ± 1.67%. Using GCMS analysis, we identified 25 compounds in whereas 26 in Four of these compounds are common in both plants. The morphological study and MTT assay revealed that both plants have antiproliferative potential as both plants exerted significant effects on the shape of the MDA-MB-231 cells and inhibited cellular proliferation in time and dose dependent manner. We conclude that both plants have potential anticancer compounds.