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Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging.
Am J Physiol Lung Cell Mol Physiol
January 2022
Laboratory of Lung Inflammation, College of Veterinary Medicine, Auburn University, Auburn, Alabama.
Asthma and its heterogeneity change with age. Increased airspace neutrophil numbers contribute to severe steroid-resistant asthma exacerbation in the elderly, which correlates with the changes seen in adults with asthma. However, whether that resembles the same disease mechanism and pathophysiology in aged and adults is poorly understood.
View Article and Find Full Text PDFSPLUNC1 comes of age? Predicting acute exacerbations in cystic fibrosis.
Eur Respir J
November 2021
Academic Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
SPLUNC1: a novel marker of cystic fibrosis exacerbations.
Eur Respir J
November 2021
Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, New Haven, CT, USA
Background: Acute pulmonary exacerbations (AE) are episodes of clinical worsening in cystic fibrosis (CF), often precipitated by infection. Timely detection is critical to minimise morbidity and lung function declines associated with acute inflammation during AE. Based on our previous observations that airway protein short palate lung nasal epithelium clone 1 (SPLUNC1) is regulated by inflammatory signals, we investigated the use of SPLUNC1 fluctuations to diagnose and predict AE in CF.
View Article and Find Full Text PDFThe effects of physical exercise and smoking habits on the expression of SPLUNC1 in nasal lavage fluids from allergic rhinitis subjects.
Int J Pediatr Otorhinolaryngol
April 2014
Department of Medical and Health Sciences, Division of Community Medicine Rehabilitation Medicine, Faculty of Health Sciences, Linköping University, and Pain and Rehabilitation Centre, County Council of Östergötland, Linköping, Sweden; Occupational and Environmental Medicine, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, and Centre of Occupational and Environmental Medicine, County Council of Östergötland, Linköping, Sweden. Electronic address:
Objective: Palate lung nasal epithelial clone (PLUNC) is a family of proteins, which are proposed to participate in the innate immune defense against infections in the upper aero-digestive tract. The aim of this study was to investigate the expression of SPLUNC1 in allergic rhinitis subjects with considerations taken to the mucosal function and smoking habits.
Methods: The participants, recruited from a cohort followed from infancy, were re-examined at the age of 18 years regarding allergy development.
Decreased SPLUNC1 expression is associated with Pseudomonas infection in surgically treated chronic rhinosinusitis patients who may require repeated sinus surgery.
Laryngoscope
April 2013
Department of Otolaryngology, China Medical University and Hospital, Taichung, Taiwan.
Objectives/hypothesis: Chronic rhinosinusitis colonized with Pseudomonas aruginosa is difficult to treat and is related to biofilm formation. Repeated sinus surgery is often required for these patients. Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) is an epithelium-secreted protein that is involved in innate immunity and has anti-Pseudomonas and antibiofilm functions.
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