AI Article Synopsis
- The study aimed to explore the effects of L-theanine on liver injury caused by ischemia-reperfusion in rats, which is a condition where blood supply to the liver is temporarily cut off and then restored.
- Thirty-two male Sprague Dawley rats were divided into four groups, some receiving L-theanine while others did not, to investigate changes in liver cell injury and function markers following induced ischemia-reperfusion.
- The results indicated that L-theanine reduced liver damage and improved various biochemical markers associated with hepatic injury, suggesting its potential protective role, though further research is necessary to confirm its effects.
Article Abstract
Objectives: The effects of L-theanine on hepatic microcirculation during hepatic ischemia-reperfusion injury have not yet been investigated. The aim of this study was to investigate the influence of L-theanine on hepatic ischemia-reperfusion injury in rats.
Materials And Methods: Thirty-two male Sprague Dawley rats weighing 250 to 300 g were used. Rats were divided into 4 groups: sham + saline, sham + L-theanine, hepatic ischemia-reperfusion injury + saline, and hepatic ischemia-reperfusion injury + L-theanine. Hepatic ischemia-reperfusion injury in rats was induced by 60 minutes of 70% ischemia and 4 hours of reperfusion. The extent of hepatic cell injury, functional capillary density, hepatic functions, and changes in some enzyme markers in hepatic tissue were investigated in the 4 groups.
Results: The induction of hepatic ischemia-reperfusion injury resulted in significant increases in hepatic necrosis; serum activity of alanine aminotransferase, lactate dehydrogenase, gamma-glutamyltransferase, and tumor necrosis factor alpha; tissue activity of inducible nitric oxide synthase, myeloperoxidase, and malondialdehyde, and oxide glutathione; and H score for hypoxia-inducible factor 1-alpha in the liver. In the liver, there were significant reductions in reduced glutathione, ratio of reduced glutathione-to-oxide glutathione, and functional capillary density. The use of L-theanine improved these changes.
Conclusions: L-theanine demonstrated protective effects on hepatic injury after ischemia-reperfusion injury in rats. However, new studies are needed to confirm the preventive or reducing effects of L-theanine on hepatic ischemia-reperfusion injury.
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| http://dx.doi.org/10.6002/ect.2021.0290 | DOI Listing |
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