A novel 3-(hydroxymethyl)-4-(methylamino)-dihydrofuran-2(3H)-one was isolated for the first time from the leaves of (Roxb.) Benth., along with kaempferol and kaempferol-3-rhamnoside . It demonstrated a promising xanthine oxidase inhibitory activity with IC values of 79.0, 0.38, and 70.4 μg/mL (allopurinol = 0.4 µg/mL). This is the first paper to describe the presence of 3-(hydroxymethyl)-4-(methylamino)dihydrofuran-2(3H)-one in the family. The structure elucidation of 3-(hydroxymethyl)-4-(methylamino)dihydrofuran-2(3H)-one , kaempferol and kaempferol-3-rhamnoside was determined primarily based on the analyses of MS and NMR results.
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| http://dx.doi.org/10.1080/14786419.2021.1999943 | DOI Listing |
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