A novel γ-lactone isolated from the leaves of (Roxb.) Benth. and its xanthine oxidase activity.

Nat Prod Res

Medicinal Chemistry Research Unit, Department of Chemistry, Faculty of Science and Technology, Thammasat University, Pathumthani, Thailand.

Published: April 2023

A novel 3-(hydroxymethyl)-4-(methylamino)-dihydrofuran-2(3H)-one was isolated for the first time from the leaves of (Roxb.) Benth., along with kaempferol and kaempferol-3-rhamnoside . It demonstrated a promising xanthine oxidase inhibitory activity with IC values of 79.0, 0.38, and 70.4 μg/mL (allopurinol = 0.4 µg/mL). This is the first paper to describe the presence of 3-(hydroxymethyl)-4-(methylamino)dihydrofuran-2(3H)-one in the family. The structure elucidation of 3-(hydroxymethyl)-4-(methylamino)dihydrofuran-2(3H)-one , kaempferol and kaempferol-3-rhamnoside was determined primarily based on the analyses of MS and NMR results.

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http://dx.doi.org/10.1080/14786419.2021.1999943DOI Listing

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