Prenylated xanthones with α-glucosidase and α-amylase inhibitory effects from the pericarp of .

Two new prenylated xanthones, mangoxanthones A-B (-), together with four known compounds -, were isolated from the ethanol extract of the pericarp of . The structures of these compounds have been elucidated based on spectroscopic analysis. The analysis results of chiral HPLC revealed compounds and were scalemic mixtures respectively. All isolated compounds were biologically evaluated for their α-glucosidase and α-amylase inhibitory effects using assays. Compound showed moderate inhibitory activities against α-glucosidase and α-amylase with IC of 29.06 ± 1.86 and 22.74 ± 2.07 μM, respectively. Molecular docking predicted the binding sites of compound to α-glucosidase and α-amylase. A preliminary structure-activity relationship was discussed.