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Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial.
Nat Med
January 2025
Department for Preventive Sports Medicine and Sports Cardiology, Technical University of Munich, School of Medicine and Health, TUM University Hospital, Munich, Germany.
Endurance exercise training (ET) is an effective treatment in heart failure with preserved ejection fraction (HFpEF), but the efficacy of resistance training in this patient population has been only scarcely evaluated. In this multicenter, randomized trial, we evaluated the effects of combined endurance and resistance training over 12 months in patients with HFpEF. The primary endpoint was a modified Packer score, including all-cause mortality, hospitalizations classified as potentially related to heart failure or exercise and changes in peak oxygen consumption ( ), diastolic function (E/e'), New York Heart Association (NYHA) class and global self-assessment (GSA).
View Article and Find Full Text PDFEnhancing colonic health with encapsulated grape seed anthocyanins: Oral capsule for Colon-targeted delivery.
Food Chem
December 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, China. Electronic address:
Grape seed anthocyanins (GSA) offer health benefits and protect against diseases, including colitis. Its unpleasant smell and instability prevent widespread application. Antisolvent pretreatment GSA was encapsulated in chitosan-phytic acid 3D gel network.
View Article and Find Full Text PDFSchool-entry age and academic difficulties at 7 years of age in children born very preterm: A call for age-corrected schooling: School-entry age and academic difficulties at 7 years of age in children born very preterm.
Arch Pediatr
December 2024
Department of Neonatology, University Hospital of Nantes, Nantes, France; LIFT Network, University Hospital of Nantes, Nantes, France.
Background: Very preterm children are at greater risk of academic difficulties (AD). Some of them start school a year earlier than anticipated during pregnancy due to being born preterm. The aim of this study was to analyze the relationship between neurodevelopment, school-entry age, and AD at age seven.
View Article and Find Full Text PDFBrain Activation Associated With Response to Psychotherapies for Late-Life Depression: A Task-Based fMRI Study.
Am J Geriatr Psychiatry
December 2024
Weill Cornell Institute of Geriatric Psychiatry (NS, LWV, ZM, GSA, FMG), Weill Cornell Medicine, White Plains, NY.
Background: The course of late-life depression is associated with functioning of multiple brain networks. Understanding the brain mechanisms associated with response to psychotherapy can inform treatment development and a personalized treatment approach. This study examined how activation of key regions of the salience network, default mode network and reward systems is associated with response to psychotherapies for late-life depression.
View Article and Find Full Text PDFTHE INCLUSION OF SEX AND GENDER IN RESEARCH METHODOLOGY, FUNDING, AND PUBLICATION: A SYSTEMATIC REVIEW.
J ISAKOS
December 2024
The Orthopedic Institute of New Jersey, 376 Layfayette Rd, Suite 202 Sparta, NJ 07871 USA. Electronic address:
Importance: Gender inequity in access to and outcomes of orthopaedic care demands research that properly analyses data based on sex and gender. Orthopaedic surgeons have an obligation to mitigate gender inequity in the provision of care by addressing the sex and gender bias in orthopaedic research methodology, grant funding, and publication demonstrated by this review.This study aimed to review the literature on known gender inequities in orthopaedic care, as well as sex and gender bias in orthopaedic research methodology, funding and publication; and to then to outline mitigating strategies.
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