Background: Nanotechnology application has successfully reached numerous scientific breakthroughs including in radiotherapy. However, the clinical application of nanoparticles requires more diligent research primarily on the crucial parameters such as nanoparticle sizes. This study is aimed to investigate the influence of bismuth oxide nanorod (BiO-NR) sizes on radiosensitization effects on MCF-7 and HeLa cell lines for megavoltage photon and electron beam radiotherapy.
Materials And Methods: MCF-7 and HeLa cells were treated with and without 0.5 μMol/L of BiO-NR of varying sizes (60, 70, 80, and 90 nm). The samples, including the control groups, were exposed to different radiation doses (0-10 Gy), using photon (6 MV and 10 MV), and electron beam (6 MeV and 12 MeV) radiotherapy. Clonogenic assay was performed, and sensitization enhancement ratio (SER) was determined from linear quadratic based cell survival curves.
Results: The results depicted that 60 nm BiO-NR yields the most excellent SER followed by 70 nm BiO-NR. Meanwhile, the 80 and 90 nm BiO-NR showed an insignificant difference between treated and untreated cell groups. This study also found that MCF-7 was subjected to more cell death compared to HeLa.
Conclusion: 60 nm BiO-NR was the optimal BiO-NR size to induce radiosensitization effects for megavoltage external beam radiotherapy. The SER in photon beam radiotherapy marked the highest compared to electron beam radiotherapy due to decreased primary radiation energy from multiple radiation interaction and higher Compton scattering.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575362 | PMC |
| http://dx.doi.org/10.5603/RPOR.a2021.0094 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of irradiation conditions on therapy of Lewis lung carcinoma in mice using glucose-ethylenediamine carbon dots.
BMC Cancer
January 2025
Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Street, Kyiv, 01601, Ukraine.
Background: nowadays, the photoacoustic imaging is in the mainstream of cancer theranostics. In this study the nanoparticles with previously proven photoacoustic imaging properties, i.e.
View Article and Find Full Text PDFTechnical note: Optimizing the deliverability of binary collimation-based SRS treatment for multiple metastases with multiple prescriptions.
Med Phys
January 2025
Department of Medical Physics, Nova Scotia Health, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.
intra-arc binary collimation (iABC) is a novel treatment technique in which dynamic conformal arcs are periodically interrupted with binary collimation. It has demonstrated its utility through planning studies for the treatment of multiple metastases. However, the binary collimation approach is idealized in the planning system, while the treatment deliveries must adhere to the physical limitations of the mechanical systems involved [e.
View Article and Find Full Text PDFQuality of life in early breast cancer patients after adjuvant accelerated partial-breast irradiation (APBI) in randomized trial.
Sci Rep
January 2025
Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Zluty kopec 7, Brno, 656 53, Czech Republic.
Accelerated partial breast irradiation (APBI) represents a valid option for adjuvant therapy of selected early breast cancer (BC). This single-institution prospective randomized study compares the health-related quality of life (HRQoL) between women treated with the highly conformal-external beam APBI technique and those with the more commonly used moderately hypofractionated whole breast irradiation (hypo-WBI). Eligible patients were women over 50 years with early BC (G1/2 DCIS ≤ 25 mm or G1/2 invasive non-lobular luminal-like HER2 negative carcinoma ≤ 20 mm) after breast-conserving surgery with negative margins.
View Article and Find Full Text PDFComparison between the SGRT and the conventional setup method for patients undergoing VMAT for pelvic malignancies.
Appl Radiat Isot
January 2025
Department of Medical Physics, Medical School, University of Crete, Heraklion, Greece. Electronic address:
Purpose: Surface Guided Radiation Treatment (SGRT) is a new method of positioning and monitoring patients on the linear accelerator's couch, using visual light cameras to monitor the skin's surface. The purpose of this study was to compare the SGRT with the conventional method, based on lasers and tattoos, in terms of accuracy and time expenditure, on patients with pelvic malignancies.
Materials And Methods: A group of 34 patients were enrolled in this study, 24 males who underwent radiotherapy prostate treatment and 10 females who underwent gynecological radiation therapy.
Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma.
Front Immunol
January 2025
Department of Dermatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, United States.
Introduction: Cutaneous T-cell lymphoma (CTCL) is closely associated with the host microbiome. While recent evidence suggests that shifts in specific bacterial taxa are associated with response to UV-B, a form of non-ionizing radiation, the impact of ionizing radiation (IR) has not been investigated.
Methods: 16S rRNA and gene amplicon sequencing were performed on DNA extracted from swabs of lesional/non-lesional skin of 12 CTCL patients before/after TSEBT or local IR and from 25 matched healthy controls (HC).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!