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The interplay of sex and genotype in disease associations: a comprehensive network analysis in the UK Biobank.
Hum Genomics
January 2025
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Richards Building B304, 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Background: Disease comorbidities and longer-term complications, arising from biologically related associations across phenotypes, can lead to increased risk of severe health outcomes. Given that many diseases exhibit sex-specific differences in their genetics, our objective was to determine whether genotype-by-sex (GxS) interactions similarly influence cross-phenotype associations. Through comparison of sex-stratified disease-disease networks (DDNs)-where nodes represent diseases and edges represent their relationships-we investigate sex differences in patterns of polygenicity and pleiotropy between diseases.
View Article and Find Full Text PDFExploration of the shared diagnostic genes and molecular mechanism between obesity and atherosclerosis via bioinformatic analysis.
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Department of Endocrinology, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250001, Shandong, China.
Obesity (OB) and atherosclerosis (AS) represent two highly prevalent and detrimental chronic diseases that are intricately linked. However, the shared genetic signatures and molecular pathways underlying these two conditions remain elusive. This study aimed to identify the shared diagnostic genes and the associated molecular mechanism between OB and AS.
View Article and Find Full Text PDFStudy on the linkage mechanism between key strata fracture in overburden and surface subsidence during caving mining in extra-thick coal seams.
Sci Rep
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Haohua Hongqingliang Mining Company, Ltd, Ordos, 014300, Inner Mongolia, China.
Caving mining in extra-thick coal seams induces large-scale overburden movement, leading to more intense fracture processes in key strata, more significant surface subsidence, and frequent dynamic disasters in mines. This study, using the N34-2 caving face of the 17th coal seam at Junde Mine as a case study, aims to investigate the time-varying linkage mechanism between surface subsidence, microseismic characteristics, and fracture scales of the overburden's key strata under such mining conditions. Based on Timoshenko's theory, a bearing fracture mode for the overburden's key strata is proposed, and corresponding fracture criteria are established.
View Article and Find Full Text PDFUnderstanding the role of metabolic syndrome in prostate cancer risk: A UK Biobank prospective cohort study.
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Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Predictive value of metabolic syndrome for prostate cancer risk is not clear. We aimed to assess the association between metabolic syndrome and its components with prostate cancer incidence. The primary outcome was prostate cancer incidence, i.
View Article and Find Full Text PDFEfficient IP address retrieval using a novel octet based encoding technique for high speed lookup to improve network performance.
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Department of Information Systems, Faculty of Computing and Information Technology, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
As the Internet becomes increasingly popular, the number of users connected to it grows significantly. Consequently, the packet processing speed of network systems, such as routers, must be enhanced. IP lookup is a critical task used to find the next hop address by searching for the longest prefix match in the forwarding information base (FIB).
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