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  • * A 52-year-old woman with a history of suspected primary adrenal insufficiency and poor treatment compliance was admitted with worsening symptoms, later diagnosed with adrenal crisis amid her COVID-19 infection.
  • * Diagnosis of adrenal insufficiency is complex due to non-specific symptoms; education and proper guidelines are essential for prevention, while further testing is needed to determine the root cause of her condition.
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THE ROLE OF INTERFERON-GAMMA RELEASE ASSAYS IN DIAGNOSIS OF LATENT TUBERCULOSIS INFECTION IN CHILDREN.

Acta Clin Croat

November 2023

Department of Pulmonology, Allergology, Rheumatology and Clinical Immunology, Zagreb Children's Hospital, Zagreb, Croatia.

Despite numerous published papers, diagnosis of latent tuberculosis infection (LTBI) in children is still an undefined area. The importance of this topic lies in the fact that one third of the world's population is infected with . The majority of infected individuals are LTBI cases which make a reservoir for future active tuberculosis (TB) patients.

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Feature fusion method for pulmonary tuberculosis patient detection based on cough sound.

PLoS One

May 2024

School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, Australia.

Since the COVID-19, cough sounds have been widely used for screening purposes. Intelligent analysis techniques have proven to be effective in detecting respiratory diseases. In 2021, there were up to 10 million TB-infected patients worldwide, with an annual growth rate of 4.

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In recent years, novel specific Mycobacteria tuberculous (TB) antigen-based skin test (TBST) has become available for clinical use. The mechanism of TBST is similar to the interferon-gamma release assay (IGRA), making it a potential alternative for identifying latent tuberculous infection (LTBI), especially in subjects with history of bacille Calmette-Guérin vaccination. Three different commercial brands have been developed in Denmark, Russia, and China.

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Background: Tuberculosis in the UK is more prevalent in people with social risk factors- e.g. previous incarceration, homelessness - and in migrants from TB endemic countries.

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