AI Article Synopsis
- Tertiary lymphoid structures and immune checkpoint inhibitors are gaining attention due to their unclear connection with renal cell carcinoma.
- Two patients with metastatic renal cell carcinoma were treated with nivolumab and ipilimumab, followed by cytoreductive nephrectomy, revealing tertiary lymphoid structures at the tumor site.
- After the surgery and a short observation period without further treatment, both patients survived, indicating a potential association between these structures and treatment response.
Article Abstract
Introduction: Tertiary lymphoid structure expression and immune checkpoint inhibitors have been attracting attention, and their relationship with renal cell carcinoma is controversial.
Case Presentation: Two patients with nivolumab plus ipilimumab treatment response for metastatic renal cell carcinoma underwent cytoreductive nephrectomy and regional lymph node dissection. In both cases, the renal tumor site expressed tertiary lymphoid structures. Despite the absence of treatment after a deferred cytoreductive nephrectomy and the short postoperative observation period, the patients still survived.
Conclusion: Tertiary lymphoid structures were expressed in deferred cytoreductive nephrectomy specimen in cases treated with nivolumab plus ipilimumab.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8560443 | PMC |
| http://dx.doi.org/10.1002/iju5.12347 | DOI Listing |
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