Inflammation is a key process in antimicrobial defence and tissue repair, and failure to properly regulate inflammation can result in tissue damage and death. Neural circuits play important roles throughout the course of an inflammatory response, and the neurophysiological and molecular mechanisms are only partly understood. Here, we review key evidence for the neural regulation of inflammation and discuss emerging technologies to further map and harness this neurophysiology, a cornerstone in the rapidly evolving field of .
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http://dx.doi.org/10.1002/cti2.1352 | DOI Listing |
J Sci Food Agric
January 2025
University of Agricultural Sciences, Bengaluru, India.
Background: The edible seeds of Ocimum gratissimum and Ocimum basilicum were found to be a potent source of phytochemicals with noteworthy antioxidant, antidiabetic, and antimicrobial properties. This study aimed to investigate the impact of germination and extraction solvents (ethanol (EtOH), distilled water) on the therapeutic properties exhibited and the ability of seed extracts to act as natural food preservatives.
Results: The EtOH extracts of germinated O.
Circ Heart Fail
January 2025
Bruce Rapport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel (I.R.H., N.K., C.B., O.C.).
Background: The therapeutic armamentarium for heart failure with preserved ejection fraction (HFpEF) remains notably constrained. A factor contributing to this problem could be the scarcity of in vitro models for HFpEF, which hinders progress in developing new therapeutic strategies. Here, we aimed at developing a novel, comorbidity-inspired, human, in vitro model for HFpEF.
View Article and Find Full Text PDFInorg Chem
January 2025
School of Clinical Medical, Hangzhou Medical College, Hangzhou 310053, China.
Chemiluminescence offers ultrasensitive imaging for the diagnosis of a variety of diseases by removing the interference from excitation light sources. Here, we prepared two chemiluminescent metal-organic frameworks (Mn-ADA and Zn-ADA) by using (2,2')-3,3'-(anthracene-9,10-diyl)diacrylic acid (ADA) as a ligand. In Mn-ADA and Zn-ADA, the Mn atoms and Zn atoms are six-coordinated and eight-coordinated, respectively, and their frameworks are different in spatial structure.
View Article and Find Full Text PDFJ Dent Sci
January 2025
Division of Molecular & Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Background/purpose: Dual-cure resin-cements are used for various dental restorations. However, whether the curing modes of these resin-cements influence gingival inflammation remains unclear. Hence, herein, we evaluated the effects of dual-cure resin-cement curing modes on gingival cytotoxicity and inflammatory responses.
View Article and Find Full Text PDFJ Dent Sci
January 2025
Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan.
Background/purpose: Peri-implantitis remains a substantial challenge. This study investigated the effect of titanium particles on human oral epithelial cells, focusing on the nucleotide-binding domain and leucine-rich repeat protein (NLRP) 3 inflammasome.
Materials And Methods: The Ca9-22 human gingival epithelial cell line was subjected to incubation with titanium particles.
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