Antibacterial and Anticancer Potentials of Presynthesized Photosensitive Oil/TiO/Polyethylene Glycol Polymeric Bionanocomposite.

The present study is concerned with the fabrication of the bifunctional oil/TiO/polyethylene glycol polymeric film for antibacterial and anticancer activities. The suggested film is based on the utility of naturally extracted oil in the formation of the polymeric bionanocomposite film decorated with TiO nanoparticles. The bionanocomposite film was fabricated by incorporating 15 w% of oil with 10 w% polyethylene glycol and 5 w% TiO nanoparticles. The active components of oil were verified using gas chromatography coupled with mass spectrometry (GC-MS). The surface morphology of the resulted bionanocomposite film was characterized by various spectroscopic and microscopic techniques. The antibacterial potential of the fabricated bionanocomposite film was investigated against four pathogenic strains. The obtained results revealed excellent sensitivity against the bacterial strains, particularly and , with minimum inhibitory concentration 320 g mL and minimum bactericidal concentration 640 and 1280 g mL for respectively. Polymeric bionanocomposite exerted significant cytotoxicity against human lung carcinoma cell lines in a concentration-dependent manner with an IC value of 42.7 ± 0.25 g mL. Safety assessment test against peripheral blood mononuclear cells (PBMCs) demonstrated that the bionanocomposite is nontoxic in nature. Bionanocomposite also showed potent photocatalytic effects. Overall, the results concluded that the bionanocomposite has expressed scope for multifaceted biomedical applications.