Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents. We report two cases with stage IV breast cancer, aged 66 and 71 years, who developed sclerodermic skin lesions in their extremities after starting treatment with placlitaxel and nabplaclitaxel respectively.
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Taxane-induced scleroderma. Report of two cases.
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Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
Taxanes are a class of chemotherapeutic agents with common associated dermatologic adverse events, such as skin hyperpigmentation, hand-foot skin syndrome, paronychia and onycholysis. Taxane-induced scleroderma is rare. Few cases with skin findings resembling systemic sclerosis, have been reported after the administration of these agents.
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Docetaxel and paclitaxel are widely used in the treatment of various malignant neoplasms. Taxane-induced sclerosis is dose-dependent and usually not generalized. Little information on the pathogenesis of scleroderma is currently available.
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Article Synopsis
- Taxanes like docetaxel and paclitaxel are chemotherapy drugs that stabilize microtubules and are effective against various solid tumors.
- In some patients, these drugs can lead to localized skin hardening, known as cutaneous sclerosis.
- A case is highlighted involving a patient with pre-existing CREST syndrome who experienced docetaxel-induced skin changes, suggesting that caution is needed when prescribing taxanes to those with a history of systemic sclerosis due to potential immune reactions.
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