AI Article Synopsis
- The study explores how low levels of triiodothyronine (T3) are linked to heart failure in 625 patients with cardiovascular issues, focusing on B-type natriuretic peptide (BNP) levels.
- Multiple regression analysis indicates that factors like left ventricular ejection fraction (LVEF), hemoglobin levels, and free T3 (FT3) are negatively correlated with BNP levels, while age shows a positive correlation.
- Structural equation modeling confirms a significant inverse relationship between FT3 and BNP, even in patients with normal BNP values, suggesting that low T3 levels are linked to higher BNP levels without necessarily indicating worse heart function.
Article Abstract
Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value (P < 0.001 each). Furthermore, the log BNP and age were significantly negatively associated with the FT3 levels, while the Hb and body mass index (BMI) were significantly positively associated with the FT3 levels (P < 0.001 each). Theoretically constructed structure equation modeling (SEM) revealed an inverse association between FT3 and BNP (β = -0.125, P = 0.002), and the same relationship remained in the patient group with normal-range BNP values (β = -0.198, P = 0.008). We demonstrated a significant relationship between high BNP and low serum FT3 levels, and this relationship remained significant in patients with normal BNP levels. These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576007 | PMC |
| http://dx.doi.org/10.1038/s41598-021-01454-5 | DOI Listing |
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