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Development of a bio-inspired wound model for debridement training.
In Vitro Model
June 2024
Department of Pharmacy, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH UK.
Unlabelled: Wound debridement is commonplace in expediting wound healing in the clinic. Despite this, there are limited resources available for simulation training for practitioners prior to facing real-life patients. Typically, citrus peels or porcine skin are employed in a vain attempt to improve debridement proficiency, yet these fail to provide a realistic experience of the textures and consistencies of wounds.
View Article and Find Full Text PDFEarly detection of canine hemangiosarcoma via cfDNA fragmentation and copy number alterations in liquid biopsies using machine learning.
Front Vet Sci
January 2025
GenesisEgo, Seoul, Republic of Korea.
Hemangiosarcoma is a highly malignant tumor commonly affecting canines, originating from endothelial cells that line blood vessels, underscoring the importance of early detection. This canine cancer is analogous to human angiosarcoma, and the development of liquid biopsies leveraging cell-free DNA (cfDNA) represents a promising step forward in early cancer diagnosis. In this study, we utilized Whole Genome Sequencing (WGS) to analyze fragment sizes and copy number alterations (CNAs) in cfDNA from 21 hemangiosarcoma-affected and 36 healthy dogs, aiming to enhance early cancer detection accuracy through machine learning models.
View Article and Find Full Text PDFEffects of stalk orientation and size of trapped bead on force-velocity relation of kinesin motor determined using single molecule optical trapping methods.
J Biol Phys
January 2025
Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Science, Beijing, 100190, China.
Conventional kinesin protein is a prototypical biological molecular motor that can step processively on microtubules towards the plus end by hydrolyzing ATP molecules, performing the biological function of intracellular transports. An important characteristic of the kinesin is the load dependence of its velocity, which is usually measured by using the single molecule optical trapping method with a large-sized bead attached to the motor stalk. Puzzlingly, even for the same kinesin, some experiments showed that the velocity is nearly independent of the forward load whereas others showed that the velocity decreases evidently with the increase in the magnitude of the forward load.
View Article and Find Full Text PDFHigh-Precision prediction of curling trajectory multivariate time series using the novel CasLSTM approach.
Sci Rep
January 2025
Department of Control Science and Engineering, Harbin Institute of Technology, Harbin, 150001, China.
As a multivariate time series, the prediction of curling trajectories is crucial for athletes to devise game strategies. However, the wide prediction range and complex data correlations present significant challenges to this task. This paper puts forward an innovative deep learning approach, CasLSTM, by introducing integrated inter-layer memory, and establishes an encoder-predictor curling trajectory forecasting model accordingly.
View Article and Find Full Text PDFWhat are the Thoughts of Women Whose Husbands' Frozen Testicular Sperm Is Thawed for in vitro Fertilization on the Day of Oocyte Retrieval? A Qualitative Study.
Int J Womens Health
January 2025
Nursing Department, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou City, Zhejiang Province, People's Republic of China.
Objective: The psychological experiences will be analyzed to understand the needs and burdens of women on the day of oocyte retrieval when the thawed testicular sperm of their husbands is used for in vitro fertilization, in order to provide a basis for the subsequent formulation of relevant nursing measures.
Methods: This study utilized a descriptive phenomenological research approach. A cohort of 13 women undergoing oocyte retrieval on the day when thawed testicular sperm from their husbands is used for in vitro fertilization at the Reproductive Medicine Center of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, between August and October 2024, were chosen as participants for this study.
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