[Study on the incidence of adult herpes zoster in Yichang city and its association with early-life famine exposure].

Based on Yichang health big data platform, 850 608 patients from September 2018 to September 2019 were included in this study. According to the date of birth, the participants were divided into early childhood famine exposure group, fetal famine exposure group and non-famine exposure group. The incidence of adult herpes zoster (HZ) in Yichang city was analyzed, and the correlation between early life famine exposure and adult HZ was analyzed. In 2019, the crude incidence rate of adult HZ in Yichang was 6.83‰. The crude incidence rate of adult HZ in females (7.26‰) was higher than that in males (6.40‰). Compared with the non-famine exposure group, fetal famine exposure was associated with the incidence of adult HZ (=1.21; 95%: 1.01-1.45, =0.041). After stratification by sex, fetal famine exposure was only found to be associated with the onset of adult HZ in females (=1.28, 95%:1.02-1.61, =0.034).