AI Article Synopsis
- Clear cell renal cell carcinoma (ccRCC) shows resistance to standard therapies, necessitating new treatment strategies, particularly due to the deletion of the von Hippel-Lindau (VHL) gene.
- Research reveals that the early growth response-1 (EGR1) protein and mRNA levels are significantly lower in ccRCC tissues, suggesting a potential link to the cancer's aggressiveness.
- Low EGR1 expression is associated with higher rates of metastasis and poor patient outcomes, identifying EGR1 as a critical independent prognostic factor and a potential target for future therapies in ccRCC patients.
Article Abstract
Clear cell renal cell carcinoma (ccRCC) is resistant to conventional therapy due to the deletion of the von Hippel-Lindau (VHL) gene, and novel treatment options are urgently needed. Here, using tissue microarray analysis of 445 cancer tissues and 326 adjacent normal renal tissues obtained from patients with ccRCC, we present the early growth response-1 (EGR1) protein levels are significantly decreased in ccRCC cancer tissues. Consistently, the EGR1 mRNA expression also decreased in cancer tissues based on the transcriptomic data for 599 tumor and normal samples from The Cancer Genome Atlas. Moreover, Patients with ccRCC presenting low EGR1 expression are more prone to exhibit metastasis and a poor prognosis than those with high EGR1 expression. By multivariate Cox regression analysis, EGR1 is determined to serve as an independent prognostic factor for patients with ccRCC. Further cellular biochemical function analyses show that EGR1 may inhibit proliferation, invasion and metastasis of ccRCC. These findings will deepen our understanding of EGR1 function and shed light on precise treatment for ccRCC patients.
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| http://dx.doi.org/10.1016/j.prp.2021.153666 | DOI Listing |
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