Introduction: Despite existing occupational lead exposure prevention regulations, Lithuanian shooting range workers still complain of chronic lead poisoning related symptoms. This indicates a poor understanding of occupational safety when working in lead-polluted environments.
Case Presentation: 20 men, whose age ranged from 32 to 57 (mean 41.8 ± 10 years), were consulted at the Toxicology Centre at the Republican Vilnius university hospital in Vilnius, Lithuania in the 2016-2019 year period. All of the patients were working as shooting instructors, with their work experience varying from 2 to 30 years. Clinical examination showed blood lead levels ranging from 5.64 μg/dL to 45.8 μg/dL (norm for occupational exposure - <40 μg/dL). Main symptoms were fatigue (12 patients out of 20), dizziness (5/20), arthralgia (5/20). Other symptoms included impaired memory (3/20), nausea (3/20), sleep disorders (3/20), metallic or sweet taste (3/20), dermatological disorders (3/20), coxarthrosis (2/20), balance disorders (2/20), paresthesia (2/20), abdominal pain (2/20) and others. 4 patients were asymptomatic.
Discussion: Shooting range employees are highly vulnerable to daily lead exposure. Even low constant elevated blood lead concentrations can have significant toxic effects over time.
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http://dx.doi.org/10.1016/j.jtemb.2021.126886 | DOI Listing |
Cell Physiol Biochem
January 2025
UR-UPJV 4667, UFR Sciences, Université de Picardie Jules Verne, Amiens, France,
Quiescent pancreatic stellate cells (PSCs) represent only a very low proportion of the pancreatic tissue, but their activation leads to stroma remodeling and fibrosis associated with pathologies such as chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). PSC activation can be induced by various stresses, including acidosis, growth factors (PDGF, TGFβ), hypoxia, high pressure, or intercellular communication with pancreatic cancer cells. Activated PSC targeting represents a promising therapeutic strategy, but little is known regarding the molecular mechanisms underlying the activation of PSCs.
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January 2025
Instituto Politécnico de Coimbra, ESTESC - Coimbra Health School, Medical Imaging and Radiotherapy, Rua 5 de Outubro, S. Martinho do Bispo, Coimbra 3046-854, Portugal. Electronic address:
Background: Currently, there is an increase in procedures across various clinical specialties involving the use of ionising radiation.
Objective: The primary objective of this systematic review is to analyse and compare the existing literature regarding the effectiveness of leaded glasses for healthcare professionals.
Methods: Comprehensive literature searches were conducted for relevant studies published between 2018 and 2023 using the Scopus, PubMed, and Web of Science databases according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) methodology.
Appl Radiat Isot
January 2025
Experimental Nuclear Physics Department, Nuclear Research Centre, Egyptian Atomic Energy Authority, Egypt; Cyclotron Facility, Egyptian Atomic Energy Authority, Egypt.
Neutron and gamma-ray shielding design for a 30Ci (1.11TBq) Am-Be irradiation facility is studied using MCNP5 Monte Carlo simulation code. The study focuses on the optimization of the shielding layers of the previously planned neutron irradiation facility.
View Article and Find Full Text PDFSci Total Environ
January 2025
School of Architecture, Southeast University, 2 Sipailou, Nanjing 210096, China.
Air-source heat pumps are popular in buildings to provide cooling and heating. However, how the air discharged by air-source heat pump outdoor units affects the dispersion of air pollutants in urban street canyons remains poorly understood. This study used coupled simulations to examine the effects that air-source heat pump outdoor units had on vehicle-induced indoor and outdoor air pollution in an urban street canyon and how these effects varied based on the arrangement of outdoor units or the presence of building envelope components (e.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention (China Medical University), Ministry of Education, Shenyang, Liaoning, China; Department of Occupational and Environmental Health, School of Public Health, China Medical University, Shenyang, Liaoning, China. Electronic address:
Deltamethrin (DM), a broad-spectrum insecticide, is widely used in the world. It can exert direct action on the central nervous system to produce neurotoxicity. Exposure to DM can lead to iron metabolism disorder, oxidative stress and learning and memory dysfunction.
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