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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782982 | PMC |
| http://dx.doi.org/10.1007/s12264-021-00788-4 | DOI Listing |
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Deletion of murine astrocytic vesicular nucleotide transporter increases anxiety and depressive-like behavior and attenuates motivation for reward.
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Article Synopsis
- Neuronal activity relies on energy sources like glucose and lactate, with lactate being provided by astrocytes, but understanding how inflammation affects this process in neurons remains unclear.
- Researchers simulated chronic low-grade inflammation by activating microglia and observed that while inflammation decreased lactate in neurons and increased it in astrocytes in isolated cultures, co-cultured systems showed the opposite effect.
- The study suggests that chronic inflammation enhances lactate supply to neurons via an astrocyte-neuron lactate shuttle but hinders the neurons' ability to use lactate effectively, impacting energy production and neuronal structure.
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