AI Article Synopsis
- An aptamer is a short DNA or RNA molecule that can selectively bind to specific targets, making it useful for biosensors in tumor imaging and treatment.
- The review highlights the benefits of using aptamers over traditional enzyme and immune sensors, showcasing various sensing methods such as electrochemistry, colorimetry, and fluorescence.
- It also discusses the future potential of aptamer-based biosensors in tumor diagnostics and monitoring after treatment.
Article Abstract
An aptamer is a short oligonucleotide chain that can specifically recognize targeting analytes. Due to its high specificity, low cost, and good biocompatibility, aptamers as the targeting elements of biosensors have been applied widely in non-invasive tumor imaging and treatment in situ to replace traditional methods. In this review, we will summarize recent advances in using aptamer-based biosensors in tumor diagnosis. After a brief introduction of the advantage of aptamers compared with enzyme sensors and immune sensors, the different sensing designs and mechanisms based on 3 signal transduction modes will be reviewed to cover different kinds of analytical methods, including: electrochemistry analysis, colorimetry analysis, and fluorescence analysis. Finally, the prospective advantages of aptamer-based biosensors in tumor theranostics and post-treatment monitoring are also evaluated in this review.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8748234 | PMC |
| http://dx.doi.org/10.1111/cas.15194 | DOI Listing |
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