MiRNA-142-3P and FUS can be Sponged by Long Noncoding RNA to Promote Cell Proliferation in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) represents a frequently occurring adulthood acute leukemia (AL). Great progresses have been achieved in the treatment of AML, but its pathogenic mechanism remains unclear. This study reported the biological functions of lncRNA in AML pathogenic mechanism. As a result, lncRNA showed high expression level within AML, resulting in poor prognosis, especially in M4 AML. studies elucidated that knockdown of with small interfering RNA (siRNA) resulted in the suppression of survival and colony formation ability, as well as induction of apoptosis, in AML cells. RNA pull-down assay and computational revealed that could sponge with miRNA-142-3P and interact with FUS protein. MiRNA-142-3P have a negative correlation with and overexpression of miRNA-142-3P inhibited cell growth in AML. Meanwhile, promoted the expression of FUS protein, targeting inhibition of FUS significantly promoted cell apoptosis in AML cell lines. In conclusion, these results revealed new mechanism of lncRNA in AML malignant behavior, and suggested that the manipulation of expression could serve as a potential strategy in AML therapy.