AI Article Synopsis
- PAS (Platelet Additive Solution) helps lower allergic reactions and delayed hemolytic transfusion reactions (DHTR) in patients receiving platelet transfusions.
- A study compared the quality of PAS-stored platelets with traditional plasma-stored platelets, measuring factors like glucose and LDH levels, but found similar overall quality between the two methods.
- The study concluded that PAS-stored platelets are effective for patients with allergic reactions and those requiring minor ABO incompatible transfusions, making it a suitable alternative for multi-transfused patients.
Article Abstract
PAS, by replacing part of the plasma in the platelet storage bag, reduces post transfusion allergic reactions and DHTR in the recipient. In this study we compared quality and efficacy of PAS and usual plasma stored platelets. Platelet concentration, content, MPV, pH, swirling, LDH and glucose concentration were tested in SDPs after preparation and on the day of transfusion; and compared between control (plasma-stored SDP) and study (PAS-stored SDP) groups. CCI was compared between the two groups. Transfusion reactions were also noted. In both groups quality parameters were similar except glucose [significantly decreased ( < 0.001) in plasma] and LDH [increased significantly (: -0.005) in PAS]. CCI was similar in both groups. Transfusion reaction rate were 0.012% and 0.049% in both groups respectively. Quality and post-transfusion efficacy in both groups were similar. PAS stored platelets may be transfused in multi-transfused patients with allergic manifestations and in minor ABO incompatible transfusions.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8523622 | PMC |
| http://dx.doi.org/10.1007/s12288-021-01408-x | DOI Listing |
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