AI Article Synopsis
- A new method using visible light was created to connect -allylbromodifluoroacetamide with quinoxalin-2(1)-ones, leading to cyclization and C-C bond formation.
- This process is conducted under mild conditions, allowing for the efficient production of various hybrid molecules.
- These novel compounds could open up new opportunities for developing complex heterocycles that may have significant biological activity.
Article Abstract
A visible light-promoted radical relay of -allylbromodifluoroacetamide with quinoxalin-2(1)-ones was developed in which 5-- cyclization and C-C bond formation were involved. This protocol was performed under mild conditions to facilely offer a variety of hybrid molecules bearing both quinoxalin-2(1)-one and 3,3-difluoro-γ-lactam motifs. These prepared novel skeletons would expand the accessible chemical space for structurally complex heterocycles with potential biological activities.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.1c02285 | DOI Listing |
Publication Analysis
Top Keywords
visible light-promoted
8
light-promoted radical
8
radical relay
8
bond formation
8
relay cyclization/c-c
4
cyclization/c-c bond
4
formation -allylbromodifluoroacetamides
4
-allylbromodifluoroacetamides quinoxalin-21-ones
4
quinoxalin-21-ones visible
4
relay -allylbromodifluoroacetamide
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!