Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107775 | PMC |
| http://dx.doi.org/10.1016/j.jid.2021.10.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hypoxia-induced degradation of FTO promotes apoptosis by unmasking RACK1-mediated activation of MTK1-JNK1/2 pathway.
J Adv Res
January 2025
College of Animal Science and Technology, Nanjing Agricultural University, Weigang 1, Nanjing 210095, China. Electronic address:
Introduction: Hypoxia, a condition characterized by inadequate oxygen supply to tissues, triggers various cellular responses, including apoptosis. The RNA demethylase FTO has been shown to exert anti-apoptotic effects, but its functions independent of RNA demethylase-particularly those involving protein-protein interactions-during hypoxia remain unclear.
Objectives: This study aimed to elucidate the cytoprotective mechanism of FTO in preventing apoptosis under hypoxic stress.
Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune response.
PLoS Pathog
November 2024
Department of Avian Infectious Diseases, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, P. R. China.
The hallmark of coronavirus infection lies in its ability to evade host immune defenses, a process intricately linked to the nuclear entry of transcription factors crucial for initiating the expression of antiviral genes. Central to this evasion strategy is the manipulation of the nucleocytoplasmic trafficking system, which serves as an effective target for the virus to modulate the expression of immune response-related genes. In this investigation, we discovered that infection with the infectious bronchitis virus (IBV) dynamically impedes the nuclear translocation of several transcription factors such as IRF3, STAT1, STAT2, NF-κB p65, and the p38 MAPK, leading to compromised transcriptional induction of key antiviral genes such as IFNβ, IFITM3, and IL-8.
View Article and Find Full Text PDFiTRAQ-Based Proteomic Analysis of Spontaneous Achilles Tendon Rupture.
J Proteome Res
January 2025
Department of Osteopathy and Orthopedics (Ankle) Surgery, The Sixth Teaching Hospital of Xinjiang Medical University, No. 39 Wuxing South Road, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.
Article Synopsis
- Spontaneous Achilles tendon rupture (SATR) mainly affects older adults with chronic injuries, but its cause and treatment options are still unclear.
- A study used iTRAQ proteomics to identify 2432 proteins in SATR patients, highlighting 307 differentially expressed proteins linked to key biological pathways, including those related to COVID-19 and extracellular matrix organization.
- Important proteins such as fibronectin and collagen types were found to be significantly affected in SATR tissues, indicating potential targets for improving diagnosis and treatment strategies.
VRK2 inhibits the replication of infectious bursal disease virus by phosphorylating RACK1 and suppressing apoptosis.
Int J Biol Macromol
January 2025
International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, PR China; Longhu Laboratory, Zhengzhou, Henan, PR China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, Henan Agricultural University, Zhengzhou, PR China. Electronic address:
Infectious bursal disease (IBD) is an acute, highly contagious, and immunosuppressive avian disease caused by the infectious bursal disease virus (IBDV). Despite significant efforts, the lack of knowledge about host proteins that counteract IBDV replication has hindered progress in preventing and controlling IBD in chickens. This study identifies the mitochondria-associated protein vaccinia virus-related kinase 2 (VRK2) as an inhibitor of IBDV.
View Article and Find Full Text PDFExosomal PSM-E inhibits macrophage M2 polarization to suppress prostate cancer metastasis through the RACK1 signaling axis.
Biomark Res
November 2024
Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, 510080, China.
Article Synopsis
- Understanding the communication between tumor-associated macrophages (TAMs) and tumor cells is essential for improving prostate cancer (PCa) prognosis, with exosomes playing a key role in this process.
- Research has shown that exosomal PSM-E is upregulated in the exosomes of PCa patients, correlating with more advanced disease stages and promoting tumor suppression by inhibiting M2 polarization of macrophages.
- The study identifies mechanisms by which exosomal PSM-E interacts with RACK1, influencing signaling pathways to reduce cancer cell proliferation and metastasis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!